Diisodecyl phthalate aggravates the formaldehyde-exposure-induced learning and memory impairment in mice

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Shuzhen GePing Ma

Abstract

Diisodecyl phthalate (DIDP) is a new type of phthalate used in the coating of pharmaceutical pills and in plastic food wrappers. This research was conducted to investigate whether DIDP could cause learning and memory impairment in mice, using formaldehyde (FA) to construct a positive control. Behavioral analysis showed that oral administration of 15 mg kg-1·d-1 DIDP combined with inhalation of 1 mg m-3 FA led to learning and memory impairment in mice. Histopathological observations of the brain showed that the pathological alterations in the hippocampi. Detection of testosterone (T) and estradiol (E2) levels in the brain and serum showed that E2 levels were associated with learning and memory disorders. Reactive oxygen species (ROS), reduced glutathione (GSH), malondialdehyde (MDA), and 8-hydroxy-2-deoxyguanosine (8-OH-dG) revealed the increased oxidative stress levels. Detection of caspase-3, NF-κB, the phosphorylated cAMP response-element binding protein (p-CREB) and the brain derived neurotrophic factor (BDNF) showed that the protective effect mediated by BDNF, is reduced. However, some of these effects were blocked by the administration of Vitmin E (VitE, 100 mg kg-1·d-1) or 17β-estradiol (17β-E2, 100 μg kg-1). These data s...Continue Reading

Citations

Mar 27, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chongyao LiPing Ma
Mar 11, 2020·Environmental Research·Fuhong LiShumao Ding
Mar 13, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Peng SongPing Ma
Aug 7, 2021·Ecotoxicology and Environmental Safety·Feng ZhanXiu-Hong Meng

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