Dilated Virchow-Robin spaces in the hippocampus impact behaviors and effects of anti-depressant treatment in model of depressed rats

Journal of Affective Disorders
Yuefeng LiShenghong Ju

Abstract

The occurrences of dilated Virchow-Robin spaces (dVRSs) and inflammatory factors were closely related with development of depression and antidepressants. The present study indicated accumulation of inflammatory factors in dVRSs played a practical role in behaviors and the treatment-resistant in rats with depression. Eighty-one male Wistar rats were exposed to chronic unpredictable mild stress (CUMS) until the model was successfully established. According to the detection of dVRSs on 7 T structural magnetic resonance imaging (MRI), rats were divided into two groups (45 CUMSnon-dVRSs rats and 36 CUMSdVRSs rats). Subsequently, different antidepressant treatment (nontreat, aspirin, fluoxetine, fluoxetine+aspirin) was given to the two groups, respectively. Sucrose preference test (SPT), forced swim test (FST) and morris water maze (MWM) was used to test the behaviors of rats. ELISA and Western blot was used to determine the levels of inflammatory factors. Compared with the negative control (NC) group, there were obvious behavioral abnormalities and increased inflammatory factors in the CUMSnon-dVRSs rats. Interestingly, these changes were more significant in the CUMSdVRSs rats. In addition, the efficacy of fluoxetine was only found ...Continue Reading

Citations

May 8, 2018·Experimental and Therapeutic Medicine·Jian CuiLongfei Li
Jan 29, 2019·Early Intervention in Psychiatry·Oliver D RobertsonSeetal Dodd
Sep 10, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Min LvFengxia Zhao
Feb 7, 2021·NPJ Parkinson's Disease·Ting ShenHsin-Yi Lai

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