Dilation of epicardial coronary arteries by the G protein-coupled estrogen receptor agonists G-1 and ICI 182,780.

Pharmacology
Matthias R MeyerMatthias Barton

Abstract

Endogenous estrogens protect from coronary artery disease in premenopausal women, but the mechanisms involved are only partly understood. This study investigated whether activation of the novel G protein-coupled estrogen receptor (GPER, formerly known as GPR30) affects coronary artery tone, and whether this is affected by concomitant blockade of estrogen receptors (ER) alpha and beta. Rings of epicardial porcine coronary arteries suspended in organ chambers were precontracted with prostaglandin F(2)alpha, and direct effects of G-1 (GPER agonist) and ICI 182,780 (GPER agonist and ERalpha/ERbeta antagonist) were determined. In addition, indirect effects on contractility to endothelin-1 and serotonin (a vasoconstrictor released from aggregating platelets during acute myocardial infarction) were assessed. ICI 182,780 and G-1 caused acute dilation of coronary arteries to a comparable degree (p < 0.05 vs. solvent control). Both GPER agonists attenuated contractions to endothelin-1 (p < 0.05 vs. ethanol), but not to serotonin (n.s.). In summary, these findings provide evidence for direct and indirect coronary artery dilator effects of GPER independent of ERalpha and ERbeta, and are the first demonstration of arterial vasodilation in r...Continue Reading

References

Sep 1, 1995·Journal of the American College of Cardiology·K SudhirK Chatterjee
Dec 17, 1997·Biochemical and Biophysical Research Communications·Y TakadaJ Ando
Apr 6, 2002·British Journal of Pharmacology·Mariarosaria BucciGiuseppe Cirino
Oct 17, 2002·Vascular Pharmacology·Richard E White
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·M P BracamonteV M Miller
Feb 12, 2005·Science·Chetana M RevankarEric R Prossnitz
Oct 28, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·I Vergote, P Abram
Mar 8, 2006·Nature Chemical Biology·Cristian G BologaEric R Prossnitz
Dec 30, 2006·Menopause : the Journal of the North American Menopause Society·Andrew P MillerSuzanne Oparil
Oct 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Pierre-André ScottJean St-Louis
Apr 29, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Nina D UllrichKenneth T MacLeod
Jan 31, 2009·Circulation Research·Elvira HaasMatthias Barton
Sep 1, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Anne M Deschamps, Elizabeth Murphy
Nov 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Jean Chrisostome BopassaEnrico Stefani
Jan 12, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Brad R S BroughtonChristopher G Sobey
Feb 26, 2010·The New England Journal of Medicine·Steven R CummingsUNKNOWN PEARL Study Investigators
Jun 19, 2010·The New England Journal of Medicine·Saul Malozowski

❮ Previous
Next ❯

Citations

Jun 13, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Young Mi SeokIn Kyeom Kim
Feb 18, 2014·Molecular and Cellular Endocrinology·Eric R Prossnitz, Matthias Barton
Feb 3, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masahiro Akishita, Jing Yu
Aug 17, 2011·Nature Reviews. Endocrinology·Eric R Prossnitz, Matthias Barton
Jul 28, 2011·American Journal of Physiology. Endocrinology and Metabolism·Xuan YuGuichun Han
Dec 29, 2011·Hypertension·Matthias R MeyerEric R Prossnitz
Jul 23, 2013·Pflügers Archiv : European journal of physiology·Oliver BaretellaPaul M Vanhoutte
Dec 18, 2013·Current Hypertension Reports·Roopashree PrabhushankarCamila Manrique
Feb 18, 2016·Life Sciences·Matthias R MeyerEric R Prossnitz
Oct 30, 2012·Experimental Physiology·G Cristina BrailoiuEugen Brailoiu
Apr 10, 2012·Pharmacology & Therapeutics·A A Knowlton, A R Lee
Jul 12, 2011·Vascular Pharmacology·Matthias R MeyerMatthias Barton
Dec 24, 2014·Scientific Reports·Matthias R MeyerEric R Prossnitz
Jan 22, 2011·British Journal of Pharmacology·Bengt-Olof NilssonL M Fredrik Leeb-Lundberg
Aug 2, 2013·Clinical and Experimental Pharmacology & Physiology·Ross D Feldman, Robert Gros
Apr 2, 2014·Clinical and Experimental Pharmacology & Physiology·Brent J F Hill, Edwin Muldrew
Sep 30, 2015·European Journal of Pharmacology·Svetlana I SofronovaOlga S Tarasova
Aug 26, 2015·The Journal of Endocrinology·Matthias R MeyerEric R Prossnitz
Jul 22, 2014·British Journal of Clinical Pharmacology·Ross D FeldmanRobert A Hegele
Feb 14, 2012·Life Sciences·Matthias R MeyerEric R Prossnitz
Mar 8, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Guichun HanRichard E White
Jan 1, 2014·Obstetrics and Gynecology International·Whitney K PetrieEric R Prossnitz
Sep 25, 2014·Annual Review of Pharmacology and Toxicology·Achim LotherLutz Hein
May 14, 2016·Expert Review of Neurotherapeutics·Hidetsugu MaekawaJuha Hernesniemi
Jun 25, 2017·Life Sciences·Pollyana PeixotoRoger Lyrio Dos Santos
Feb 17, 2018·British Journal of Pharmacology·Margaret A MouatNicola J Smith
Feb 4, 2016·Circulation Research·Sara Menazza, Elizabeth Murphy
Sep 8, 2016·Hypertension·Brasilina CarocciaGian Paolo Rossi
Sep 8, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Mallikarjuna R PabbidiSumit P Sontakke
Jul 10, 2014·American Journal of Physiology. Endocrinology and Metabolism·Xuan YuGuichun Han

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.