PMID: 8951199Nov 1, 1996Paper

Diltiazem does not always increase blood cyclosporin concentration

British Journal of Clinical Pharmacology
T E Jones, R G Morris

Abstract

The pharmacokinetic interaction between the calcium channel blocking drug, diltiazem (DTZ), the antifungal agent itraconazole (ICZ) and the immunosuppressive drug cyclosporin (CsA) was studied in a patient with a single lung transplant. The CsA area under curve estimations demonstrated a significant increase when ICZ was co-prescribed (5836 micrograms l-1 h vs 8159 micrograms l-1 h) but no increase when DTZ was co-prescribed with CsA (5836 micrograms l-1 h vs 5069 micrograms l-1 h). Despite widespread use as a CsA-sparing agent, DTZ does not always increase CsA concentrations.

References

Dec 14, 1991·Lancet·J C KolarsP B Watkins
Jan 1, 1990·European Journal of Clinical Pharmacology·J BrockmöllerI Roots
Aug 30, 1986·Lancet·H H Neumayer, K Wagner
Sep 7, 1995·The New England Journal of Medicine·A KeoghA Kaan
Feb 1, 1993·Transplantation·A ChrysostomouT H Mathew

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Citations

May 23, 1998·Annual Review of Pharmacology and Toxicology·K E Thummel, G R Wilkinson
Oct 22, 2008·Nutrition & Metabolism·Zakia Bibi
Feb 27, 1999·Journal of Clinical Pharmacy and Therapeutics·E Tanaka
Dec 17, 2003·Clinical Pharmacokinetics·Martin R Farlow
Aug 26, 1998·Therapeutic Drug Monitoring·R G Morris, T E Jones

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