Dilution is effective in reducing infusion phlebitis in peripheral parenteral nutrition: an experimental study in rabbits

Nutrition
T KuwaharaS Kubo

Abstract

To clarify conflicting clinical results that had been reported as to whether dilution is effective or not in reducing infusion phlebitis, this study was undertaken. We undertook two experiments with the different infusion conditions in rabbits to confirm the generality and the reproducibility of the results. To test the effect of dilution, 120 mL/kg of solution A (784 mOsm/kg) was infused into rabbit ear veins at 10 mL.kg-1.h-1 for 12 h, and 144 mL/kg of 1.2-fold-diluted solution A (648 mOsm/kg) was infused at 12 mL.kg-1.h-1 for 12 h. Similarly, 120 mL/kg of solution B (718 mOsm/kg) was infused at 5 mL.kg-1.h-1 for 24 h, and 168 mL/kg of 1.4-fold-diluted solution B (514 mOsm/kg) was infused at 7 mL.kg-1.h-1 for 24 h. The infused veins were sampled 24 h after the end of the infusion and examined histopathologically. After the 12-h infusion, phlebitic changes were observed in six of eight rabbits given solution A but in only one of eight rabbits given diluted solution A, although the same quantities of the same nutrients were infused. Also, after the 24-h infusion, phlebitic changes were observed in six of eight rabbits given solution B but in no animals given diluted solution B. The same result that dilution reduced or eliminate...Continue Reading

References

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Citations

Aug 13, 2008·International Journal of Medical Sciences·Emiko KohnoKenji Matsuyama
Jun 1, 2014·Cancer Chemotherapy and Pharmacology·Zhuo WangDingfeng Su
Apr 24, 2015·Journal of Pediatric Gastroenterology and Nutrition·Mehmet DemircanBulent Mizrak
Feb 11, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Antoine PetitcollinHélène Bourgoin
Dec 4, 2009·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Kathleen M Gura
Apr 5, 2017·Journal of Intensive Care Medicine·Ryan C DillonJohn Papadopoulos
Apr 16, 2004·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Girolamo A OrtolanoBarry Wenz
Apr 20, 2021·Frontiers in Veterinary Science·Elke Rudloff, Kate Hopper

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