Dilution of rocuronium to 0.5 mg/mL with 0.9% NaCl eliminates the pain during intravenous injection in awake patients.

Anesthesia and Analgesia
Bahattin TuncaliZahide Elar

Abstract

In a randomized, double-blinded, controlled study, we evaluated the effect of diluting rocuronium 10 mg/mL to 1 or 0.5 mg/mL with 0.9% NaCl on the pain associated with IV administration of rocuronium with small doses given before succinylcholine or nondepolarizing agent administration. One hundred fifty patients undergoing surgical procedures that required general anesthesia were randomized into three groups. Group 1 received rocuronium 10 mg/mL. Groups 2 and 3 received 1 and 0.5 mg/mL of rocuronium, respectively. Patient demographics, pain scores, osmolality, and the pH of the solutions were recorded. Group 1 had the most intense and frequent pain response. Eighty percent of patients in this group reported pain on injection. In Group 2, the incidence and intensity of pain were significantly less when compared with those of Group 1. In this group, 38% of patients reported pain during injection. In Group 3, none of the patients experienced pain on injection. The pH values and osmolalities of study solutions were not significantly different among groups. In conclusion, in awake patients, dilution of rocuronium 10 mg/mL at small doses given before succinylcholine or nondepolarizing agent administration of 0.06 mg/kg to 0.5 mg/mL w...Continue Reading

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Citations

Mar 15, 2011·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Guy D LaRue, Martin Peterson
Mar 9, 2012·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Zeynep Nur AkcaboyNermin Gogus
Oct 17, 2009·Journal of Clinical Anesthesia·Yong Cheol LeeSang Gyu Lee
Mar 4, 2008·Paediatric Anaesthesia·Seung-Hoon BaekSang-Wook Shin
Jul 10, 2014·Korean journal of anesthesiology·Hye Jin ParkJeong Sung Seo
Jan 6, 2012·Korean journal of anesthesiology·Young Hee ShinSang Hyun Kim
Feb 13, 2016·The Cochrane Database of Systematic Reviews·Hemanshu PrabhakarMartha A Smith
May 3, 2008·Yonsei Medical Journal·Byung In ChoiKi-Young Lee
Jan 31, 2020·Saudi Journal of Anaesthesia·Fumio WatanabeMitsunori Miyazu
Oct 27, 2006·British Journal of Anaesthesia·J Y KimH J Kwak

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