Dilution potential: a new perspective

Pharmaceutical Development and Technology
Y HabibR Shangraw

Abstract

The objective of this work was to develop a method to assess the dilution capacity of direct compression excipients based on a technique previously proposed by Minchom and Armstrong (MA). The technique involves the addition of increasing quantities of a poorly compactible (compressible) material to the excipient and measuring the resultant decrease in the AUC of the tensile strength versus compaction force profiles. The AUC of each mixture is divided by the AUC of the "0% mixture" to obtain MA's "work potential," called "area ratios" in the present study. The applicability of this approach was tested using three excipients differing in their deformation mechanisms: microcrystalline cellulose (Avicel PH 101, 102, 200, 301, 302) representing a plastic material; dibasic calcium phosphate (Cal-Star) representing a brittle material, and anhydrous lactose, which exhibits both brittle and plastic properties. Ascorbic acid or acetaminophen was the poorly compactible challenge material. In the first study, the MA method was found to apply only to Avicel PH 101, since the area ratios for mixtures containing different compositions of acetaminophen with either Cal-Star or anhydrous lactose remain constant until a certain percentage of drug...Continue Reading

References

Aug 1, 1968·The Journal of Pharmacy and Pharmacology·J T Fell, J M Newton

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Citations

Jun 17, 2004·AAPS PharmSciTech·Yeli ZhangSibu Chakrabarti
Sep 13, 2014·Drug Development and Industrial Pharmacy·Vikas MoolchandaniStephen W Hoag
Jul 15, 2015·Drug Development and Industrial Pharmacy·Vikas MoolchandaniStephen W Hoag
Apr 26, 2020·Bio-medical Materials and Engineering·Jomjai PeerapattanaMakoto Otsuka
Apr 8, 2020·Advances in Pharmacological and Pharmaceutical Sciences·Afewerk GetachewSolomon Abrha

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