Dimenhydrinate decreases vomiting after strabismus surgery in children

Anesthesia and Analgesia
D F VenerJ Lerman

Abstract

Dimenhydrinate, an H1-receptor antagonist, has been used to both prevent and treat postoperative vomiting (POV) in children for several decades. However, its effectiveness for POV after strabismus surgery remains anecdotal. This study was designed to determine the effectiveness and side effects of dimenhydrinate for the prevention of POV in children after strabismus surgery. Eighty ASA physical status I or II children, ages 1-12 yr inclusive, who were undergoing strabismus surgery, were prospectively and randomly allocated to receive either dimenhydrinate 0.5 mg/kg intravenously (n = 40) or placebo (n = 40) at induction of anesthesia. The incidence of POV and the times to arousal (and discharge from the recovery room and hospital) were recorded postoperatively in a double blinded manner. For 24 h after discharge from the hospital, all emetic episodes and medications given were recorded by the parents. Demographic data did not differ between the groups. Children who received dimenhydrinate had significantly less POV both inhospital (10%) and overall (30%) than those who received placebo (in-hospital 38%, P < 0.008; overall 65%, P < 0.003). The times to arousal and discharge from the hospital did not differ between the two groups...Continue Reading

References

Jan 1, 1992·British Journal of Anaesthesia·J Lerman
Jul 1, 1992·Anesthesiology·M F Watcha, P F White
Apr 1, 1990·Biopharmaceutics & Drug Disposition·J M ScavoneD J Greenblatt
Nov 1, 1982·Anaesthesia and Intensive Care·M P Rowley, T C Brown
Dec 1, 1982·Anaesthesia·J Pfenninger, M Sutter
May 1, 1981·Canadian Anaesthetists' Society Journal·L RitaF Seleny
Apr 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J Lerman
May 1, 1952·Anesthesiology·R H HUME, W K WILNER

❮ Previous
Next ❯

Citations

Aug 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·W M SplinterD J Roberts
Aug 18, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C A Stockall
Jan 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K MikawaH Obara
Aug 25, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·L H EberhartM Georgieff
Aug 31, 1999·Survey of Ophthalmology·C E Margo
Nov 15, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Matthias VoigtHeinz Kerger
Oct 23, 2002·Paediatric Drugs·Pasquale De Negri, Giorgio Ivani
Feb 13, 2007·Paediatric Drugs·Anthony L Kovac
Aug 18, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J L ParlowN Avery
Aug 12, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F E Simons
Sep 14, 2011·Journal of Clinical Anesthesia·Matthias VoigtHeinz Kerger
Sep 19, 2000·British Journal of Anaesthesia·A SchlagerF Pühringer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.