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Dimensionality and the statistical power of multivariate genome-wide association studies

bioRxiv

Mar 17, 2015

Eladio J. Márquez, David Houle

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Abstract

Mutations virtually always have pleiotropic effects, yet most genome-wide association studies (GWAS) analyze effects one trait at a time. In order to investigate the performance of a multivariate approach to GWAS, we simulated scenarios where variation in a d-dimensional phenotype space...read more

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  • Dimensionality and the statistical power of multivariate genome-wide association studies

    bioRxiv

    Mar 17, 2015

    Eladio J. Márquez, David Houle

    PMID: 990016592

    DOI: 10.1101/016592

    Abstract

    Mutations virtually always have pleiotropic effects, yet most genome-wide association studies (GWAS) analyze effects one trait at a time. In order to investigate the performance of a multivariate approach to GWAS, we simulated scenarios where variation in a d-dimensional phenotype space...read more

    8
    22
    Paper Details
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