PMID: 9165087Mar 1, 1997Paper

Dimer interface of glutathione S-transferase from Arabidopsis thaliana: influence of the G-site architecture on the dimer interface and implications for classification

Biological Chemistry
L PradeB Bieseler

Abstract

The three-dimensional structure of glutathione S-transferase from Arabidopsis thaliana has been solved at 2.2 A resolution (Reinemer et al., 1996). The enzyme forms a dimer of two identical subunits. The structure shows a new G-site architecture and a novel and unique dimer interface. Each monomer of the protein forms a separate G-site. Therefore, the requirements on the dimer interface are reduced. As a consequence, the interactions between the monomers are weaker and residues at the dimer interface are more variable. Thus, the dimer interface looses its relevance for a classification of plant glutathione S-transferases and the formation of heterodimers becomes even more difficult to predict.

References

Nov 28, 1979·Biochemical and Biophysical Research Communications·M Bruschi, P Couchoud
Nov 5, 1978·Journal of Molecular Biology·V V BorisovA E Braunstein
Dec 18, 1991·European Journal of Biochemistry·R Jaenicke
Mar 1, 1991·The Biochemical Journal·D J MeyerB Ketterer
Jun 20, 1991·Journal of Molecular Biology·C R KissingerL H Jensen
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M KarpusasB W Matthews
Jan 1, 1988·CRC Critical Reviews in Biochemistry·B Mannervik, U H Danielson
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J BelfaizaI Saint-Girons
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H C Dunathan, J G Voet
Apr 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·H C Dunathan
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·G C FordJ N Jansonius
Jul 20, 1993·Journal of Molecular Biology·V Daggett, M Levitt
Mar 1, 1993·Journal of Biotechnology·C von der OstenJ M Mikkelsen
Mar 16, 1994·Biochimica Et Biophysica Acta·M C Wilce, M W Parker
Jan 1, 1993·Protein Engineering·G J Barton
Jan 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R Jaenicke
May 1, 1996·Nature Structural Biology·H X ZhouW F DeGrado

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.