Dimeric drug polymeric nanoparticles with exceptionally high drug loading and quantitative loading efficiency

Journal of the American Chemical Society
Kaimin CaiJianjun Cheng

Abstract

Encapsulation of small-molecule drugs in hydrophobic polymers or amphiphilic copolymers has been extensively used for preparing polymeric nanoparticles (NPs). The loadings and loading efficiencies of a wide range of drugs in polymeric NPs, however, tend to be very low. In this Communication, we report a strategy to prepare polymeric NPs with exceptionally high drug loading (>50%) and quantitative loading efficiency. Specifically, a dimeric drug conjugate bearing a trigger-responsive domain was designed and used as the core-constructing unit of the NPs. Upon co-precipitation of the dimeric drug and methoxypoly(ethylene glycol)-block-polylactide (mPEG-PLA), NPs with a dimeric drug core and a polymer shell were formed. The high-drug-loading NPs showed excellent stability in physiological conditions. No premature drug or prodrug release was observed in PBS solution without triggering, while external triggering led to controlled release of drug in its authentic form.

References

Oct 8, 1998·Pharmacy World & Science : PWS·V M HerbenJ H Beijnen
Sep 7, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·H S YooT G Park
Apr 6, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Leyang ZhangYong Hua Yang
May 27, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sergio A Galindo-RodríguezHatem Fessi
Sep 23, 2006·Nature Reviews. Cancer·Yves Pommier
Jul 14, 2007·Advanced Drug Delivery Reviews·Valentino J Stella, Kwame W Nti-Addae
Mar 8, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lev Bromberg
Mar 14, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kyung Hyun MinIck Chan Kwon
Apr 15, 2008·Advanced Drug Delivery Reviews·Yasuhiro Matsumura
Jul 26, 2008·Nature Nanotechnology·Dan PeerRobert Langer
Mar 12, 2010·Journal of the American Chemical Society·Youqing ShenWilliam J Murdoch
Jul 10, 2010·Nature Reviews. Drug Discovery·Robby A Petros, Joseph M DeSimone
Feb 25, 2011·Journal of the American Chemical Society·Dissaya PornpattananangkulLiangfang Zhang
Oct 5, 2011·ACS Nano·Ki Young ChoiJae Hyung Park
Nov 15, 2011·Biomaterials·Kuan-Ju ChenHsian-Rong Tseng
Jan 24, 2012·Advanced Drug Delivery Reviews·Yapei WangJoseph M DeSimone
Dec 25, 2012·ACS Chemical Biology·Yves Pommier
Apr 13, 2013·Chemical Reviews·Min Hee LeeJong Seung Kim
May 8, 2013·Angewandte Chemie·Yanfeng ZhangJianjun Cheng
Jun 7, 2013·Advanced Materials·Jinqiang WangZhongwei Gu
Aug 24, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Jing XuLiyan Qiu
Nov 5, 2013·Colloids and Surfaces. B, Biointerfaces·Yan-Ling LuoBin Zhang
Nov 28, 2013·ACS Nano·Liang MaAndrew Smith
Oct 5, 2014·Colloids and Surfaces. B, Biointerfaces·Josimar Oliveira EloyJuliana Maldonado Marchetti
Oct 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Li TangJianjun Cheng

❮ Previous
Next ❯

Citations

Dec 30, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Meysam MobasheriMahmoud Reza Jaafari
Dec 8, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Min TianJinqiang Jiang
Apr 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Quanbing MouDeyue Yan
May 4, 2016·International Journal of Pharmaceutics·Tsuf Croitoru-SadgerBoaz Mizrahi
Aug 2, 2016·Biomacromolecules·Zhun ZhouDennis Bong
Oct 22, 2016·Biomaterials·Si-Yong QinXian-Zheng Zhang
Jan 11, 2017·ACS Applied Materials & Interfaces·Lei ZhangShaobing Zhou
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Pablo BotellaAlejandro Cabrera-García
Apr 14, 2017·Bioorganic & Medicinal Chemistry Letters·Zhanfeng WangZhigang Xie
Dec 20, 2015·Chemistry : a European Journal·Manish S HudlikarGeert-Jan Boons
Dec 17, 2017·Journal of Labelled Compounds & Radiopharmaceuticals·Anping JiMinghua Du
Nov 7, 2017·Organic & Biomolecular Chemistry·Zijun ZhouZhigang Xie
Aug 14, 2018·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Paula M CastilloRafael Prado-Gotor
Oct 12, 2018·Cell and Tissue Research·Nazish TabassumBirbal Singh
Aug 1, 2019·Angewandte Chemie·Guangze YangChun-Xia Zhao
Nov 14, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yunlong YuShiyong Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.