Dimeric Pimprinine Alkaloids From Soil-Derived Streptomyces sp. NEAU-C99

Frontiers in Chemistry
Zhiyin YuSheng-Xiong Huang

Abstract

Six new pimprinine alkaloids (1-6), including four dimers, dipimprinines A-D (1-4), and two monomers, (±)-Pimprinol D (5), and pimprinone A (6), along with six known congeners (7-12), were isolated from a soil-derived actinomycete Streptomyces sp. NEAU-C99. Structures of the new compounds were elucidated by extensive spectroscopic analyses, single-crystal X-ray diffractions, and ECD calculations. Dipimprinines A-D (1-4) showed weak cytotoxic activities against five tumor cell lines, including HL-60, SMMC-7721, A-549, MCF-7, and SW-480, with IC50 values ranging from 12.7 to 30.7 μM.

References

Dec 28, 2002·Journal of Natural Products·George R PettitJean M Schmidt
May 9, 2012·European Journal of Medicinal Chemistry·Ming-Zhi ZhangJohn Clough
Feb 23, 2013·Biochimica Et Biophysica Acta·Gordon M Cragg, David J Newman
Jun 13, 2013·The Journal of Antibiotics·Paranee SripreechasakYoko Takahashi
Oct 11, 2017·Journal of Natural Products·Ruimin YangSheng-Xiong Huang
Jan 1, 2019·Chinese Journal of Natural Medicines·Guo-Xun YangJin-Feng Hu
Jan 27, 2019·Journal of Agricultural and Food Chemistry·Bin LiuQingmin Wang

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Citations

May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Songya ZhangTao Liu
May 23, 2021·The Journal of Antibiotics·Manli LiuWei Fang

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Datasets Mentioned

BETA
MN647558
JN999913.1
CCDC1964253

Methods Mentioned

BETA
circular dichroism
column chromatography
NMR
X-ray

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