PMID: 653736Feb 1, 1978Paper

Dimethadione-induced fetotoxicity in rats

Toxicology
H S ButtarK S Khera

Abstract

The fetotoxic potential of dimethadione was studied in rats given single daily oral dosages of 0, 54, 433 or 541 mg/kg on days 1--21 or 6--15 of gestation. No maternal toxicity was observed following treatment on days 6--15. When administered from days 1 to 21 only the highest dose (541 mg/kg) produced a significant reduction in maternal body weight gain. Dimethadione caused a dose-related decrease in fetal weight and an increased incidence of umbilical hernia, ecchymoses and subcutaneous edema. There were also increased incidences of non-specific skeleton defects which consisted of unilateral or bilateral wavy ribs, additional ribs (14th rib, uni- and bilateral), retarded ossification of calvaria and a wide variety of sternal defects. Specific defects were bent radius and ulna, and bent tibia and fibula which increased with increasing dosages of dimethadione. Fetal mortality and incidence of skeletal anomalies were higher when the treatment was given on days 1--21 of gestation than on days 6--15 of pregnancy.

Citations

Jan 1, 1988·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K S Khera, C Whalen
Aug 1, 1979·Epilepsia·K K MidhaI Dupuis
Sep 17, 2009·Pediatric Surgery International·Dennis R Van DorpMichael D Klein
Aug 1, 1994·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·A Kast
Aug 28, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kristiina L AasaTerence R S Ozolinš
Dec 25, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Edward W Carney, Carole A Kimmel
Sep 25, 2014·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Carole A KimmelJohn M DeSesso
Feb 23, 2007·Birth Defects Research. Part C, Embryo Today : Reviews·Andrea D WestonNigel A Brown
Dec 1, 2011·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Elizabeth PurssellTerence R S Ozolinš
Apr 29, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Bhavesh K Ahir, Margaret K Pratten
Oct 2, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Aldert H PiersmaWout Slob

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.