Dimethyl fumarate-induced IL-17low IFN-γlow IL-4+ Th cells protect mice from severe encephalomyelitis

European Journal of Immunology
Jürgen BrückKamran Ghoreschi

Abstract

Dimethyl fumarate (DMF) promotes an IL-17Alow IFN-γlow IL-4+ CD4+ T cell phenotype. Adoptive transfer of in vitro DMF-treated myelin peptide-reactive IL-17Alow IFN-γlow IL-4+ CD4+ T cells prior to immunization for EAE reduces the severity of encephalomyelitis. This beneficial effect of transferred DMF-treated CD4+ T cells requires an early in vivo recall.

References

Oct 12, 2011·The Journal of Experimental Medicine·Kamran GhoreschiMartin Röcken
Jan 15, 2016·Neurology. Neuroimmunology and Neuroinflammation·Catharina C GrossLuisa Klotz
Apr 15, 2016·Proceedings of the National Academy of Sciences of the United States of America·Ulf Schulze-TopphoffScott S Zamvil
Mar 5, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qi WuYang Mao-Draayer
Nov 7, 2017·European Journal of Immunology·Matthew D SmithPavan Bhargava

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