PMID: 6410963Jan 1, 1983Paper

Dimethyl sulfoxide effects on platelet aggregation and vascular reactivity in pial microcirculation

Annals of the New York Academy of Sciences
W Rosenblum

Abstract

DMSO is a hydroxyl radical scavenger that inhibits platelet aggregation in vivo in injured microvessels, and that also inhibits the dilation displayed by pial arterioles following a local injury. The injurious stimulus is a result of local excitation of circulating sodium fluorescein by an appropriate light source. It is likely that this excitation results in the generation of hydroxyl radicals, which are the immediately injurious agent. This postulate is supported not only by the inhibitory effect of DMSO but also by the inhibitory effect of glycerol, another hydroxyl scavenger. Both the hypothesis that DMSO inhibits hydroxyl-mediated dilation, and the hypothesis that free radicals can dilate pial arterioles, are further supported by direct evidence from studies employing local application of xanthine oxidase plus acetaldehyde. This well established radical-generating system dilated pial arterioles. The dilation was inhibited by the local application of superoxide dismutase and also by local application of catalase, as well as by intraperitoneal administration of DMSO. Since DMSO failed to inhibit the dilation produced by increases of inspired CO2, we believe that the inhibitory effect of DMSO on the other dilating stimuli in ...Continue Reading

References

Mar 1, 1977·Circulation Research·W I Rosenblum, F El-Sabban
May 1, 1977·Stroke; a Journal of Cerebral Circulation·H A KontosJ L Patterson
Apr 17, 1976·Lancet·O LarssonK Barber
Jan 27, 1975·Annals of the New York Academy of Sciences·P Görög, I B Kovács
Nov 1, 1976·Stroke; a Journal of Cerebral Circulation·J C de la Torre, J W Surgeon
Jan 1, 1975·Annual Review of Biochemistry·I Fridovich
Jul 22, 1975·Biochemical and Biophysical Research Communications·H W Cook, W E Lands
May 1, 1976·Stroke; a Journal of Cerebral Circulation·W I Rosenblum
Feb 1, 1967·Journal of Applied Physiology·H Wayland, P C Johnson

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Citations

Jun 24, 2005·Australian Veterinary Journal·B W Sykes, M O Furr
Oct 14, 2014·Drug and Chemical Toxicology·Taygun Timocin, Hasan B Ila
Jul 8, 2009·The Veterinary Clinics of North America. Equine Practice·Gal Kelmer
Mar 22, 2008·Equine Veterinary Journal·G KelmerF M Andrews
Jun 1, 1987·Acta Paediatrica Japonica; Overseas Edition·N SakuragawaM Arima
Dec 16, 2003·American Journal of Veterinary Research·Cedric L C TuttLinda S Jacobson
Jan 29, 2014·Faraday Discussions·Ning LiuPatrik Schmuki
Nov 17, 2016·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Francesca RiboniPatrik Schmuki
Jan 28, 2021·Bone & Joint Research·Pouya AkhbariChinmay M Gupte

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