Jan 27, 1975

Dimethyl sulfoxide in central nervous system trauma

Annals of the New York Academy of Sciences
J C De la TorreS Mullan

Abstract

Dimethyl sulfoxide has been tested in various experimental injuries of the central nervous system in relation to other therapies. It appears to be a useful drug in acute extradural mass-forming lesions, middle cerebral artery occlusion, respiratory anoxia, and spinal cord injuries, in rhesus and squirrel monkeys, dogs, and rats. The data from these studies suggest that in the experimental models used, DMSO is clearly superior to no treatment, and appears to be more generally effective than other comparable treatments. No satisfactory answer has yet been found to explain the beneficial effects of DMSO, but several hypothetical suggestions are offered; their validation hinges primarily on further confirmatory evidence. Further experiments with our present models and alternative research lines are discussed.

Mentioned in this Paper

Post-Traumatic Myelopathy
Mild Traumatic Brain Injury
Dimethyl Sulfoxide
Infarction, Middle Cerebral Artery
Genus Saimiri
Motor Skills
Malignant Neoplasm of Spinal Cord
Brain
Entire Central Nervous System
Neoplasm of Uncertain or Unknown Behavior of Spinal Cord

About this Paper

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