Dimethylarginine dimethylaminohydrolase inhibition and asymmetric dimethylarginine accumulation contribute to endothelial dysfunction in rats exposed to glycosylated protein: effects of aminoguanidine

Atherosclerosis
Qing-Feng YinYan Xiong

Abstract

To determine whether alterations of endogenous asymmetric dimethylarginine (ADMA) concentration and dimethylarginine dimethylaminohydrolase (DDAH) activity are involved in endothelial dysfunction induced by glycosylated bovine serum albumin (GBSA) in rats and effects of aminoguanidine on them. Endothelium-dependent relaxation of aortic rings from Sprague-Dawley rats after treatment with GBSA in vitro and in vivo was tested. Serum concentrations of ADMA, nitrite/nitrate, and activities of aortic DDAH, nitric oxide synthase (NOS) and superoxide dismutase were measured in GBSA-treated rats. Moreover, serum contents of glycosylated serum protein, and malondialdehyde were also assayed. Endothelium-dependent relaxation was significantly impaired either by incubation of aortic rings with GBSA (1.70mmol/l) in vitro for 60min or by injection of GBSA (35mg/kg/d, i.v.) to normal rats for 4 weeks, and serum ADMA levels were remarkably elevated in GBSA-treated rats, which was accompanied by decreases of nitrite/nitrate concentrations, NOS and DDAH activities. Furthermore, elevated glycosylated serum protein, malondialdehyde levels, and reduced superoxide dismutase activity were also observed in GBSA-treated rats. Treatment with aminoguanidi...Continue Reading

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Citations

Apr 8, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Na ChenYan Xiong
Nov 23, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Li-Hua LiuYan Xiong
Apr 1, 2009·Expert Opinion on Drug Metabolism & Toxicology·Carol Wadham, Arduino A Mangoni
Mar 8, 2011·Journal of the Formosan Medical Association = Taiwan Yi Zhi·You-Lin Tain, Li-Tung Huang
Jul 1, 2008·Proteomics. Clinical Applications·Sebastian A PotthoffOliver Vonend
May 15, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shu Yan YuGang Li
Mar 19, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shu Yan YuShuanglian Wang
Oct 16, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Fredrik PalmChristopher S Wilcox

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