Dimethylarginine metabolism during acute and chronic rejection of rat renal allografts.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Dariusz ZakrzewiczVeronika Grau

Abstract

Dimethylarginines are inhibitors of NO synthesis and are involved in the pathogenesis of vascular diseases. In this study, we ask the question if asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) levels change during fatal and reversible acute rejection, and contribute to the pathogenesis of chronic vasculopathy. The Dark Agouti to Lewis rat strain combination was used to investigate fatal acute rejection. Fischer 344 kidneys were transplanted to Lewis rats to study reversible acute rejection episode and the process of chronic rejection. Isograft recipients and untreated Lewis rats were used as controls. l-arginine derivatives were determined by HPLC, and ADMA-metabolizing enzymes were studied by quantitative RT-PCR and western blotting. Renal transplantation transiently increased dimethylarginine levels independent of acute rejection. ADMA plasma levels did not importantly differ between recipients undergoing fatal or reversible acute rejection, whereas SDMA was even lower in recipients of Fisher 344 grafts. In comparison to isograft recipients, ADMA and SDMA levels were slightly elevated during reversible, but not during the process of chronic rejection. Increased dimethylarginine levels, however, did n...Continue Reading

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Citations

Jun 25, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kathleen J ClaesPieter Evenepoel
Dec 4, 2012·International Journal of Molecular Sciences·Dariusz ZakrzewiczMalgorzata Wygrecka
Apr 5, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Michael SkwirbaVeronika Grau
Sep 24, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Weizheng ZhouYang Yuan
Aug 15, 2014·BioMed Research International·Marion MeixnerVeronika Grau
Feb 27, 2015·Transplantation·Anna ZakrzewiczVeronika Grau
Aug 9, 2020·Clinical Science·Chunyun Zhang, Shougang Zhuang
Feb 26, 2021·Oxidative Medicine and Cellular Longevity·Ewa WojtaszekJolanta Malyszko

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

SPSS

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