Diminished ability of erythrocytes from patients with systemic lupus erythematosus to limit opsonized immune complex deposition on leukocytes and activation of granulocytes

Arthritis and Rheumatism
C H NielsenR G Leslie

Abstract

To compare the ability of normal erythrocytes and erythrocytes from systemic lupus erythematosus (SLE) patients to bind immune complexes (IC), thereby inhibiting IC deposition on polymorphonuclear leukocytes (PMN) and the consequent induction of a PMN respiratory burst (RB). The binding of fluorescein isothiocyanate-labeled IC in 75% autologous serum to whole blood cells or isolated leukocytes from 17 SLE patients and 10 controls was assessed by flow cytometry. Reactive oxygen metabolite (ROM) production by PMN was measured as the intracellular oxidation of dihydrorhodamine 123, on stimulation with unlabeled IC. Erythrocyte-mediated inhibition of IC uptake by PMN reached a mean +/- SD maximum of 68 +/- 18% in controls and 29 +/- 51% in SLE patients (P < 0.05) and, in the patients, correlated inversely with disease activity. In the presence of erythrocytes from various donors, IC binding to a standard preparation of PMN and their ROM production were inversely proportional to the number of type 1 complement receptors (CR1) per donor erythrocyte. Thus, the ROM production was higher in the presence of SLE patients' erythrocytes (125 +/- 67 CR1/erythrocyte) than with erythrocytes from controls (235 +/- 118 CR1/erythrocyte). Erythroc...Continue Reading

References

Apr 1, 1991·Clinical and Experimental Immunology·N MadiJ A Schifferli
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Citations

Sep 29, 2005·Rheumatology International·Helmut SoerensenWolfgang Ramlow
Mar 13, 2016·Autoimmunity Reviews·Christoffer T NielsenSøren Jacobsen
Dec 18, 2001·Phytotherapy Research : PTR·M StefanescuG Szegli
Apr 15, 2017·Lupus Science & Medicine·Line Kjær WinbergSøren Jacobsen
Apr 23, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Line Kjaer WinbergSøren Jacobsen

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