Diminished amygdala activation and behavioral threat response following traumatic brain injury

Experimental Neurology
Christopher P PalmerAkiva S Cohen

Abstract

Each year, approximately 3.8 million people suffer mild to moderate traumatic brain injuries (mTBI) that result in an array of neuropsychological symptoms and disorders. Despite these alarming statistics, the neurological bases of these persistent, debilitating neuropsychological symptoms are currently poorly understood. In this study we examined the effects of mTBI on the amygdala, a brain structure known to be critically involved in the processing of emotional stimuli. Seven days after lateral fluid percussion injury (LFPI), mice underwent a series of physiological and behavioral experiments to assess amygdala function. Brain-injured mice exhibited a decreased threat response in a cued fear conditioning paradigm, congruent with a decrease in amygdala excitability determined with basolateral amygdala (BLA) field excitatory post-synaptic potentials together with voltage-sensitive dye imaging (VSD). Furthermore, beyond exposing a general decrease in the excitability of the primary input of the amygdala, the lateral amygdala (LA), VSD also revealed a decrease in the relative strength or activation of internuclear amygdala circuit projections after LFPI. Thus, not only does activation of the LA require increased stimulation, but t...Continue Reading

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Citations

Dec 2, 2017·Journal of Neuroscience Research·Eric J NeubergerVijayalakshmi Santhakumar
Sep 19, 2017·The International Journal of Neuroscience·Jun-Xi DaiYang Wang
Nov 17, 2020·Frontiers in Behavioral Neuroscience·Jennifer BlazeFatemeh Haghighi
Dec 29, 2020·Brain Research·Yulia K KomlevaAlla B Salmina
Sep 29, 2019·Frontiers in Neuroendocrinology·Zachary M Weil, Kate Karelina
Mar 23, 2021·Frontiers in Behavioral Neuroscience·Taylor A McCorkleRamesh Raghupathi
Oct 15, 2020·Journal of Neurotrauma·Juliana PopovitzHita Adwanikar

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