PMID: 2493966Feb 13, 1989Paper

Diminished calcium currents in aged hippocampal dentate gyrus granule neurones

Brain Research
J N Reynolds, P L Carlen

Abstract

Voltage-dependent calcium currents in hippocampal dentate gyrus granule neurons of young adult (4-6 months) and aged (24-26 months) Fischer 344 rats have been examined using single-electrode voltage-clamp techniques. Calcium currents, especially a high threshold slowly inactivating L-type current, were significantly depressed in neurons obtained from aged animals. Furthermore, these age-dependent changes could be reversed by intracellular injection of the calcium chelator, ethylene glycol bis-(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA). These results are in agreement with the hypothesis that aging results in a persistent increase in the free cytoplasmic calcium concentration in mammalian central neurons.

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Citations

Aug 15, 1996·European Journal of Pharmacology·B McGahon, M A Lynch
Jan 1, 1996·Life Sciences·S Kirischuk, A Verkhratsky
Apr 1, 1991·Mechanisms of Ageing and Development·V V FrolkisA N Timchenko
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Feb 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John C GantPhilip W Landfield
Dec 3, 2013·European Journal of Pharmacology·J C GantP W Landfield
Jul 26, 2005·Experimental Neurology·Alexander TonkikhPeter L Carlen
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Jul 11, 1998·Journal of Neurophysiology·D Murchison, W H Griffith
Jul 1, 1996·Neurobiology of Aging·H HartmannW E Müller

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