Diminished gray matter density mediates chemotherapy dosage-related cognitive impairment in breast cancer patients

Scientific Reports
Xiu LiHuaidong Cheng

Abstract

To investigate chemotherapy dosage-related cognitive impairment and its neural mechanisms in breast cancer (BC) patients. Twenty-eight breast cancer patients after each chemotherapy cycle and matched 29 healthy control subjects underwent structural magnetic resonance imaging. Voxel-based morphometry analysis was performed to compare group differences in the gray matter for the whole brain. Furthermore, mediation analysis was conducted to explore the role of brain structures in chemotherapy dosage-related cognitive impairment. Voxel-based morphometry analysis was performed in gray matter for the whole brain of BC patients after chemotherapy. The results revealed that the gray matter density in the left inferior frontal gyrus, right middle frontal gyrus, right fusiform area, and bilateral cerebellum was decreased in the BC patients compared to controls. The number of chemotherapy cycles was negatively associated with general cognitive capacity, verbal fluency and digit span performance in the BC patients. In addition, decreased gray matter density in the right middle frontal gyrus could mediate the chemotherapy dosage effects on verbal fluency performance. These findings indicate that the dose-response relationship between chemot...Continue Reading

References

May 12, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·R SchlösserJ D Brodie
Sep 6, 2007·Neuropsychology Review·María Beatriz Jurado, Mónica Rosselli
Oct 14, 2008·NeuroImage·Gerard R RidgwayNick C Fox
Aug 7, 2010·Breast Cancer Research and Treatment·Brenna C McDonaldAndrew J Saykin
Dec 21, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sabine DeprezStefan Sunaert
Aug 29, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Heather S L JimBrent J Small
Sep 1, 2012·Psycho-oncology·Barbara CollinsAndra Smith
Sep 15, 2012·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Noriko Ando-TanabeHitoshi Miyaoka
May 11, 2013·Neuroscience and Biobehavioral Reviews·Marta SimóJordi Bruna
Mar 19, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Jochen KaiserJörg Dietrich
Mar 25, 2014·Journal of the International Neuropsychological Society : JINS·Kim Edelstein, Lori J Bernstein
Jul 10, 2014·Breast Cancer Research and Treatment·Ying ZhengQi Dai
Dec 29, 2016·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Pok-Ja Oh

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Citations

Apr 27, 2020·Brain Imaging and Behavior·Charlotte SleursSabine Deprez
Jul 1, 2020·Current Neurology and Neuroscience Reports·David Schiff, Mossaed Alyahya
Oct 18, 2020·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Yun FengLong Jiang Zhang
Mar 19, 2021·Scientific Reports·Rebecca A HarrisonShelli R Kesler
Aug 10, 2021·ACS Chemical Neuroscience·Alan UmfressJames A Bibb
Aug 18, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Brenna C McDonald
Aug 30, 2021·Neuroscience and Biobehavioral Reviews·Lori J BernsteinClaude Alain

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Software Mentioned

SPSS
DARTEL
3dClustSim
SPM12
VBM8
SPM8
MATLAB
BrainNet Viewer

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