Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance

Human Reproduction
S J MorinE Seli

Abstract

Do infertile women aged <38 years with quantitative evidence of diminished ovarian reserve and/or poor response to stimulation also exhibit poor oocyte quality as measured by blastulation rates, aneuploidy rates, and live birth rates? Young women with evidence of accelerated follicular depletion, either by precycle ovarian reserve testing or postcycle evidence of low oocyte yield, exhibit equivalent blastulation rates, aneuploidy rates and live birth rates per euploid embryo transfer as age-matched controls with normal precycle and postcycle parameters. Previous studies are conflicted as to whether women with evidence of diminished ovarian reserve and/or poor ovarian response are also at increased risk of exhibiting evidence of poor oocyte quality. Most prior studies have failed to adequately control for the confounding effect of female age on typical markers of oocyte quality in poor responders. The rate of follicular depletion occurs at around 38 years on average; thus, evidence of quantitative depletion before this would indicate a premature diminution of ovarian reserve and allow evaluation of whether markers of oocyte quality are tied to quantitative markers. This was a retrospective cohort study at a single center between...Continue Reading

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Citations

Jan 29, 2019·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Safak HatirnazSamer Tannus
Jan 18, 2020·Human Fertility : Journal of the British Fertility Society·Berrin AvciGurkan Uncu
May 28, 2019·Human Reproduction·Jori A LeijdekkersUNKNOWN OPTIMIST study group
Jan 20, 2020·Journal of Assisted Reproduction and Genetics·Luis R HoyosMousa Shamonki
Apr 15, 2020·Journal of Assisted Reproduction and Genetics·Jie DengRuth B Lathi
Nov 25, 2020·Seminars in Reproductive Medicine·Hayden Anthony Homer
Oct 20, 2019·Reproductive Biomedicine Online·Pierre-Emmanuel BouetPascale May-Panloup
Jan 16, 2021·Human Fertility : Journal of the British Fertility Society·Anne-Sophie CornilleTiphaine Lefebvre
Mar 15, 2019·Current Opinion in Obstetrics & Gynecology·Baris AtaEmre Seli
Feb 8, 2021·Reproductive Biomedicine Online·Guvenc KarlıkayaMustafa Bahceci
Feb 13, 2021·Environmental Health and Preventive Medicine·Hannah KimTae Ki Yoon
Mar 12, 2021·Frontiers in Endocrinology·Antonia ChristodoulakiBjörn Heindryckx
May 20, 2020·Journal of Gynecology Obstetrics and Human Reproduction·Banu SevenYaprak Engin-Ustun
Mar 20, 2021·Reproductive Biomedicine Online·Haiqing TianXiaolin La
Apr 15, 2021·Reproductive Biomedicine Online·Angela PipariJuan A Garcia-Velasco
Mar 27, 2021·Current Opinion in Obstetrics & Gynecology·Hayden Anthony Homer
Oct 3, 2021·Journal of Assisted Reproduction and Genetics·Mette W ChristensenHans Jakob Ingerslev
Jan 4, 2022·Journal of Assisted Reproduction and Genetics·C E GordonA Lanes
Jan 11, 2022·American Journal of Reproductive Immunology : AJRI·Nannan ZhaoHong Li

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