Diminished ovarian reserve in recurrent pregnancy loss: a systematic review and meta-analysis

Fertility and Sterility
Sarah J BunnewellSiobhan Quenby

Abstract

To evaluate the association between diminished ovarian reserve (DOR) in women at risk of recurrent pregnancy loss (RPL) using ovarian reserve tests. Systematic review and meta-analysis. University medical schools. Women with a history of RPL. Systematic reviews of major electronic databases (MEDLINE, EMBASE, Web of Science, and Scopus) for studies that evaluated the incidence of DOR in women with RPL. Association between RPL and DOR. In studies up to May 2019 we assessed quality using the Newcastle-Ottawa Scale and meta-analyzed data using a random-effect model. We included 15 studies (n = 3,082 women) reporting on six ovarian reserve tests: antimüllerian hormone [AMH], antral follicle count, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, and FSH:LH ratio. More women with RPL seemed to have DOR compared with women who did not have RPL as measured by low AMH levels (odds ratio [OR] 2.77; 95% confidence interval [CI], 1.41-5.46) and AFC (OR 2.45; 95% CI, 1.16-5.19). Women with unexplained RPL also seemed to have a higher association with DOR compared with women whose RPL had a known etiology, as measured by low AMH levels (OR 3.23; 95% CI, 1.81-5.76). No statistically significant differences were found i...Continue Reading

Citations

Jun 27, 2020·Current Opinion in Obstetrics & Gynecology·Ralph S Papas, William H Kutteh
Oct 6, 2020·Prenatal Diagnosis·Svetlana A YatsenkoAleksandar Rajkovic
Feb 3, 2021·Zeitschrift für Geburtshilfe und Neonatologie·Taylan OnatEthem Serdar Yalvac
May 1, 2021·Reproductive Biomedicine Online·Elias M Dahdouh, William H Kutteh
Jul 14, 2021·Human Reproduction Update·Andrea BusnelliPaolo Emanuele Levi-Setti
Jul 31, 2021·The Application of Clinical Genetics·Ralph S Papas, William H Kutteh
Aug 23, 2021·Current Opinion in Obstetrics & Gynecology·Orestis TsonisStamatina Iliodromiti

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