Diminished parietal cortex activity associated with poor motion direction discrimination performance in schizophrenia.

Cerebral Cortex
Jun WangBrett A Clementz

Abstract

The results of multiple investigations indicate visual motion-processing abnormalities in schizophrenia. There is little information, however, about the time course and neural correlates of motion-processing abnormalities among these subjects. For the present study, 13 schizophrenia and 13 healthy subjects performed a simple motion direction discrimination task with peripherally presented moving grating stimuli (5 or 10 deg/s). Dense-array electroencephalography data were collected simultaneously. The goal was to discern whether neural deviations associated with motion-processing abnormalities among schizophrenia patients occur early or late in the visual-processing stream. Schizophrenia patients were worse at judging the direction of motion gratings, had enhanced early neural activity (about 90 ms after stimulus onset), and deficient target detection-related late neural activity over parietal cortex (about 400 ms after stimulus onset). In addition, there was a strong association (accounting for 36% of performance variance) between poor behavioral performance and lower target detection-related brain activity among schizophrenia patients. These findings suggest that abnormalities in later stages of motion-processing mechanisms, ...Continue Reading

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Citations

Aug 7, 2012·European Archives of Psychiatry and Clinical Neuroscience·Lia Lira Olivier SandersPhilipp Sterzer
Aug 30, 2011·Brain and Cognition·Daniel J NortonYue Chen
Apr 12, 2012·Synapse·Alejandro Valdés-CruzGonzalo Flores
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Apr 19, 2017·Psychophysiology·Matthew E Hudgens-HaneyBrett A Clementz
Jun 26, 2021·NeuroImage·Roberto F Salamanca-GironFriedhelm C Hummel

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