Diminished production of type-I interferons and interleukin-2 in patients with multiple sclerosis

Journal of the Neurological Sciences
K P WandingerH Kirchner

Abstract

Several lines of evidence have supported the role of immunological mechanisms in the pathogenesis of multiple sclerosis (MS) and new immunomodulatory strategies for its treatment, e.g. subcutaneous application of interferon (IFN)-beta, have emerged. We investigated the ability of peripheral blood mononuclear cells (PBMC) in 21 consecutive patients with clinically definite MS to produce interferons and lymphokines in response to viral or mitogenic stimulation. Ten patients showed clinical signs of disease activity (acute relapse) and 11 patients were in a stable condition. Additionally, white blood count, leukocyte differentiation and lymphocyte subtyping were performed. A group of age-related healthy blood donors served as control (n=20). There was no difference between patients and controls in the production of IFN-gamma, tumor necrosis factor (TNF)-alpha and soluble interleukin (IL)-2 receptor. IFN-alpha and IFN-beta responsiveness, however, was significantly lower in patients with stable disease than in patients with active disease and controls (p<0.001). Furthermore, secretion of IL-2 after stimulation was significantly diminished in both patient groups as compared to the control group (p<0.01). Analysis of T-cell subsets r...Continue Reading

References

Jan 1, 1990·Annals of the New York Academy of Sciences·J E Merrill
Apr 1, 1990·Journal of Neuroscience Research·P K Haugen, P C Letourneau
Oct 1, 1987·Journal of Neurochemistry·E N BenvenisteJ N Whitaker
Jun 8, 1985·Lancet·W A SibleyK Clark
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R P SanetoJ de Vellis
May 1, 1981·Neurology·P A NeighbourB R Bloom
Jan 1, 1982·Journal of Immunological Methods·H KirchnerW Digel
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Apr 1, 1995·Annals of Neurology·B Cannella, C S Raine
Jul 7, 1995·Annals of the New York Academy of Sciences·J R RichertC K Hurley
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·P B ChallonerM Chang
Apr 1, 1995·Annals of Neurology·H F McFarland
Feb 11, 1995·BMJ : British Medical Journal·W I McDonald
May 1, 1994·Clinical Neurology and Neurosurgery·C M Poser
Jan 1, 1994·Annals of Neurology·J Hillert
Jan 1, 1994·Annals of Neurology·H S Panitch
Nov 1, 1995·Journal of the Neurological Sciences·H KlüterH Kirchner
Jan 1, 1995·Duodecim; lääketieteellinen aikakauskirja·M PaneliusJ Ruutiainen

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Citations

Apr 8, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J A Todd
Jun 12, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Marcin M KamińskiKarsten Gülow
Jul 3, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Giulio PoddaBruno Gran
Feb 13, 2001·Journal of Neuroimmunology·J R OksenbergS L Hauser
Jul 20, 2002·Clinical Neurology and Neurosurgery·Reinhard Horowski
Dec 24, 2008·Pharmacogenomics·Saskia VosslamberCornelis L Verweij
Oct 19, 2005·Pharmacology & Therapeutics·Adil Javed, Anthony T Reder
May 23, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yazhong TaoSilva Markovic-Plese
Feb 16, 2017·Clinical & Translational Immunology·Michael P PenderScott R Burrows
May 25, 2002·Scandinavian Journal of Immunology·J Lang, D Bellgrau
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julie K Olson, Stephen D Miller

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Methods Mentioned

BETA
flow cytometry
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS

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