Diminished Reactive Hematopoiesis and Cardiac Inflammation in a Mouse Model of Recurrent Myocardial Infarction.

Journal of the American College of Cardiology
Sebastian CremerMatthias Nahrendorf

Abstract

Recurrent myocardial infarction (MI) is common in patients with coronary artery disease and is associated with high mortality. Long-term reprogramming of myeloid progenitors occurs in response to inflammatory stimuli and alters the organism's response to secondary inflammatory challenges. This study examined the effect of recurrent MI on bone marrow response and cardiac inflammation. The investigators developed a surgical mouse model in which 2 subsequent MIs affected different left ventricular regions in the same mouse. Recurrent MI was induced by ligating the left circumflex artery followed by the left anterior descending coronary artery branch. The study characterized the resulting ischemia by whole-heart fluorescent coronary angiography after optical organ clearing and by cardiac magnetic resonance imaging. A first MI-induced bone marrow "memory" via a circulating signal, reducing hematopoietic maintenance factor expression in bone marrow macrophages. This dampened the organism's reaction to subsequent events. Despite a similar extent of injury according to troponin levels, recurrent MI caused reduced emergency hematopoiesis and less leukocytosis than a first MI. Consequently, fewer leukocytes migrated to the ischemic myoca...Continue Reading

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Citations

Mar 12, 2020·Nature Reviews. Cardiology·Karina Huynh
Jul 1, 2020·F1000Research·Claire Fielding, Simón Méndez-Ferrer
Nov 20, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Ioannis MitroulisTriantafyllos Chavakis
Nov 1, 2020·Current Opinion in Immunology·Rysa ZamanSlava Epelman
Mar 5, 2020·Journal of the American College of Cardiology·Ziad Mallat, Jean-Sébastien Hulot
Feb 2, 2021·Endocrine Reviews·Adil Rasheed, Katey J Rayner
Jun 23, 2021·Cardio-Oncology·Rudolf A de BoerSherry-Ann Brown
Jun 12, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Merry L LindseyKeith R Brunt
Jul 29, 2021·Heart Failure Reviews·Iacopo FabianiAlberto Giannoni
Aug 7, 2021·Advances in Wound Care·Norifumi UraoGayathri Ganesh
Sep 12, 2020·Journal of the American College of Cardiology·Aurora SemeranoMarco Bacigaluppi
Sep 18, 2021·Cardiovascular Research·Sreejit GopalkrishnaPrabhakara R Nagareddy

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