Diminished response to tick-borne encephalitis vaccination in thymectomized children

Vaccine
Martina PrelogReinhard Wuerzner

Abstract

In order to analyze the clinical impact of immunological alterations in thymectomized children after exposure to a new antigen (tick-borne encephalitis virus (TBEV) vaccine), 17 thymectomized children completed a three-dose immunization regimen. Thymectomized children showed significantly lower TBEV IgG antibody levels after the second vaccination when compared to healthy age-matched controls (n=30) (p=0.03), but a normal response after the third vaccination. Age at thymectomy correlated significantly with the TBEV IgG antibody levels (p=0.04). Thymectomized children also showed significantly lower total counts and percentages for naïve T cells correlating with time after thymectomy (p=0.02), than observed for controls. These changes in T cell subsets and the decreased ability to respond to new antigens in thymectomized children, as observed here, may precede more striking effects such as higher infection rates or autoimmune conditions as they age.

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Citations

Sep 23, 2009·The Journal of Clinical Investigation·Delphine SauceVictor Appay
Aug 14, 2009·Rejuvenation Research·Manuela Zlamy, Martina Prelog
Nov 16, 2012·Expert Review of Vaccines·Herwig KollaritschAlan Barrett
Jul 15, 2011·Current Opinion in Immunology·Delphine Sauce, Victor Appay
Nov 4, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Martina PrelogBeatrix Grubeck-Loebenstein
Sep 24, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Martina PrelogHans H Hirsch
Jul 1, 2011·World Journal for Pediatric & Congenital Heart Surgery·Heidi M HermesAnne M Stevens
Jun 23, 2018·Stress : the International Journal on the Biology of Stress·M Nazmul HudaKevin D Laugero
Aug 2, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P TabaI Steiner
Feb 6, 2017·Frontiers in Immunology·Susana L SilvaAna E Sousa
Jul 12, 2017·European Journal of Immunology·Theo van den BroekFemke van Wijk

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