Dimyristoylphosphatidic acid/cholesterol bilayers. Thermodynamic properties and kinetics of the phase transition as studied by the pressure jump relaxation technique

European Biophysics Journal : EBJ
A Blume, M Hillmann

Abstract

Lipid bilayers and monolayers composed of dimyristoylphosphatidic acid (DMPA) and cholesterol were characterized by differential scanning calorimetry and film balance measurements. Increasing cholesterol content decreases the bilayer phase transition temperature and enthalpy in a manner similar to that observed before for other lipid/cholesterol systems. In monomolecular films at the air-water interface cholesterol exhibits the well known condensing effect in the liquid-expanded phase, while the liquid-condensed phase is less affected. As with the bilayer phase transition, the transition temperature and change in area at the liquid-condensed to liquid-expanded phase transition, as measured from isobars at 25 dynes/cm, decreases with increasing cholesterol content. The kinetics of the phase transition of DMPA/cholesterol bilayers were measured using the pressure jump relaxation technique with optical detection. Three relaxation times were observed. The relaxation times and amplitudes pass through maximum values at the transition midpoint. With increasing cholesterol content the maximum values of the relaxation times decrease but not in a linear fashion. The time constants display an intermediate maximum at ca. 10% to 12 mol% cho...Continue Reading

Citations

Nov 19, 2009·European Biophysics Journal : EBJ·Martin Schiewek, Alfred Blume
Oct 3, 2008·European Biophysics Journal : EBJ·Martin Schiewek, Alfred Blume
Jun 14, 2012·Physical Chemistry Chemical Physics : PCCP·Izumi IwakuraTakayoshi Kobayashi
May 5, 2007·The Review of Scientific Instruments·Martin SchiewekAlfred Blume
Nov 21, 2007·The Journal of Physical Chemistry. B·Heiko M SeegerThomas Heimburg
Oct 1, 1988·Chemistry and Physics of Lipids·G LipkaH Hauser
Feb 27, 1989·Biochimica Et Biophysica Acta·L Cruzeiro-HanssonO G Mouritsen
Mar 20, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Prachya MruetusatornC Patrick Collier
Nov 8, 2012·The Journal of Physical Chemistry. B·Sureshbabu NagarajanR Brian Dyer

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