PMID: 6971239Feb 1, 1981Paper

Dinitrochlorobenzene-induced colitis in the guinea-pig: studies of colonic lamina propria lymphocytes

Gut
M E Glick, Z M Falchuk

Abstract

Dinitrochlorobenzene-induced colitis in guinea-pigs may be immunologically mediated: animals must be presensitised to dinitrochlorobenzene to develop colitis, sensitivity can be passively transferred by lymphocytes and the injury can be mitigated by immunosuppression. In this study, we examined lamina propria lymphocytes isolated from colons of animals with dinitrochlorobenzene-induced colitis, and appropriate controls. Lamina propria lymphocytes from colitis animals have a greater percentage of rabbit erythrocyte-rosetting cells (T cells) (20.1 +/- 3.0 vs 2.3 +/- 0.8, p less than .01) and a greater capacity to mediate mitogen-induced cellular cytotoxicity with phytohaemagglutinin than lamina propria lymphocytes from normal colon (% specific cytoxicity = 29.4 +/- 8.7 vs 5.0 +/- 4.5, P less than .005). There was no difference in the percentage of rosetting cells or cytotoxicity index of spleen or mesenteric lymph node lymphocytes between the colitis animals and controls. These data suggest that there are changes in the distribution and functional characteristics of lamina propria lymphocytes which correlate with mucosal cell injury in the dinitrochlorobenzene-colitis model.

References

May 1, 1977·The Journal of Clinical Investigation·D M Bull, M A Bookman
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Citations

Dec 1, 1985·Digestive Diseases and Sciences·W Strober
Sep 14, 2001·Journal of Veterinary Pharmacology and Therapeutics·V Herak-PerkovićM Pogacnik
Apr 8, 1982·The New England Journal of Medicine·J B Kirsner, R G Shorter
Feb 28, 2002·Annual Review of Immunology·Warren StroberRichard S Blumberg
Jan 1, 1992·Scandinavian Journal of Gastroenterology·T BrkićD E Hernandez
Dec 15, 2015·Pharmacognosy Magazine·Phani Krishna KondamudiRekha Raghuveer Shenoy
Oct 1, 1991·Disease-a-month : DM·J B Kirsner
Jul 1, 1992·Scandinavian Journal of Gastroenterology·H S Kim, A Berstad
Nov 8, 2003·World Journal of Gastroenterology : WJG·Wen-Bin Xiao, Yu-Lan Liu
Jun 5, 1998·The American Journal of Physiology·A D KraneveldF P Nijkamp

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