PMID: 8950355Nov 4, 1996Paper

Dinitrochlorobenzene is genotoxic by sister chromatid exchange in human skin fibroblasts

Mutation Research
L D DeLeve

Abstract

Dinitrochlorobenzene (DNCB) is clinically efficacious in the therapy of alopecia areata, but its use was limited when it was found to be mutagenic in the Ames test. However, there has been renewed interest in the immunomodulatory benefits of topically applied dinitrochlorobenzene in patients with human immunodeficiency virus and systemic lupus erythematosus. The current study examines the genotoxicity of dinitrochlorobenzene in human skin fibroblasts using sister chromatid exchange. Dinitrochlorobenzene caused a significant increase in sister chromatid exchange at concentrations ranging from 2.5 to 10 microM. Thus, dinitrochlorobenzene is genotoxic in human skin fibroblasts at concentrations well below those used clinically. The potential for long-term toxicity from dinitrochlorobenzene will have to be weighed against the severity and prognosis of the diseases for which it is used.

References

Aug 1, 1991·Immunology Letters·R B Stricker, B F Elswood
Mar 1, 1985·Archives of Dermatology·H S BlackJ Gerguis
Nov 11, 1995·Lancet·R B Stricker, B Goldberg
Sep 1, 1993·Mutation Research·J D TuckerA V Carrano
Sep 1, 1994·Journal of the American Academy of Dermatology·R B StrickerW L Epstein

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Citations

Mar 5, 2016·Autoimmunity Reviews·Takashi Yoshimasu, Fukumi Furukawa
Feb 14, 2014·Journal of Surgical Oncology·Diona L DamianJohn F Thompson
Jul 24, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·G SzolnokyL Kemény
Apr 19, 2015·Clinics in Dermatology·Nikki D HillAdelaide A Hebert
Sep 18, 2016·Clinics in Dermatology·Oliverio Welsh
Feb 6, 2007·Journal of the American Academy of Dermatology·Diona L Damian, John F Thompson
Sep 5, 2001·The British Journal of Dermatology·D A Buckley, A W Du Vivier
Feb 15, 2018·Dermatology and Therapy·Nicola ZerbinatiRossano Valsecchi
Dec 7, 2013·Expert Review of Clinical Immunology·Ryan M TrowbridgeDevendra K Agrawal

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