Dinitrosopiperazine-decreased PKP3 through upregulating miR-149 participates in nasopharyngeal carcinoma metastasis

Molecular Carcinogenesis
Yuejin LiFaqing Tang

Abstract

Nasopharyngeal carcinoma (NPC) has a high metastatic clinicopathological feature. As a carcinogen factor, N,N'-dinitrosopiperazine (DNP) is involved in NPC metastasis, but its precise mechanism has not been fully elucidated. Herein, we showed that DNP promotes NPC metastasis through upregulating miR-149. DNP was found to decrease Plakophilin3 (PKP3) expression, further DNP-decreased PKP3 was verified to be through upregulating miR-149. We also found that DNP induced proliferation, adhesion, migration and invasion of NPC cell, which was inhibited by miR-149-inhibitor. DNP may promote NPC metastasis through miR-149-decreased PKP3 expression. Therefore, DNP-increased miR-149 expression may be an important factor of NPC high metastasis, and miR-149 may serve as a molecular target for anti-metastasis therapy of NPC.

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Citations

Dec 19, 2019·Cell and Tissue Research·Ilse Hofmann
Oct 24, 2020·Signal Transduction and Targeted Therapy·Yuanbo KangLei Wang
Jul 3, 2021·Biomolecules·Yin-Qiao LiuWang-Kai Fang
Oct 12, 2021·Frontiers in Cell and Developmental Biology·Lisa MüllerRené Keil

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Methods Mentioned

BETA
PCR
transfect
transfection
Protein Assay
biopsy
Assay
flow cytometry
fluorescence microscopy
transfections
chips

Software Mentioned

SPSS
ImageJ

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