Dinosaur senescence: a hadrosauroid with age-related diseases brings a new perspective of "old" dinosaurs.

Scientific Reports
Justyna SłowiakDawid Surmik

Abstract

Senile vertebrates are extremely rare in the fossil record, making their recognition difficult. Here we present the largest known representative of the Late Cretaceous hadrosauriform Gobihadros mongoliensis showing features of cessation of growth indicating attainment of the terminal size. Moreover, this is the first non-avian dinosaur with an age-related pathology recognized as primary calcium pyrophosphate deposition disease indicating its advanced age. Because senile dinosaurs are so rare and thus "senescence" in dinosaurs is unclear, we also propose a new unified definition of a senile dinosaur: an individual which achieved the terminal size as revealed by the presence of the external fundamental system and closed transcortical channels, has completely secondary remodeled weight-bearing bones and possesses non-traumatic, non-contagious bone pathologies correlated with advanced age.

References

Aug 16, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·V ShidhamG Shidham
Nov 16, 2002·Lancet·Bruce RothschildCliff Miles
Jun 4, 2005·Science·Mary H SchweitzerJohn R Horner
Mar 7, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·João Pedro de MagalhãesGeorge M Church
Jan 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Andrew H Lee, Sarah Werning
May 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Robert E Ricklefs
Jul 23, 2013·PloS One·Fiona R StraehlMarcelo R Sánchez-Villagra
Oct 16, 2015·BMC Evolutionary Biology·Hannah S MumbyVirpi Lummaa
Feb 19, 2016·Biology Letters·David W E HoneMathew J Wedel
Oct 1, 2016·Current Rheumatology Reports·Chio YokoseSvetlana Krasnokutsky
Mar 22, 2019·Nature Communications·Alida M BailleulZhonghe Zhou
May 30, 2020·Anatomia, histologia, embryologia·Bruce M RothschildLarry Martin
Nov 26, 2020·Proceedings. Biological Sciences·Thomas M CullenPeter J Makovicky
Dec 9, 2020·Biological Reviews of the Cambridge Philosophical Society·Christopher T GriffinSterling J Nesbitt
Dec 23, 2020·Proceedings. Biological Sciences·Petra FrýdlováDaniel Frynta

❮ Previous
Next ❯

Software Mentioned

Paint 3D apps
MeshLab
EXScan Pro
Volume Graphics® MyVGL viewer
3D Viewer
Elements
NIS
GOM Inspect

Related Concepts

Related Feeds

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
P Dodson
Evolution; International Journal of Organic Evolution
Peter Dodson
Current Biology : CB
Michael J Benton
Biological Reviews of the Cambridge Philosophical Society
Stephen L BrusatteThomas E Williamson
© 2021 Meta ULC. All rights reserved