Dinucleotide-sensing proteins: linking signaling networks and regulating transcription

Science Signaling
H K LambA R Hawkins

Abstract

Differential binding of dinucleotides to key regulatory proteins can modulate their interactions with other proteins and, in some cases, can signal fluctuations in the cellular redox state, to produce changes in transcription and physiological state. The dinucleotide-binding proteins human HSCARG and yeast transcription repressor Gal80p are examples that offer exciting glimpses into the potential for dinucleotide-sensing proteins to couple fluctuations in dinucleotide ratios to changes in transcription and to act as networking agents linking different classes of signaling molecules.

References

May 30, 1998·The Journal of Biological Chemistry·W N TianR C Stanton
Feb 16, 2002·Science·Qinghong ZhangRichard H Goodman
May 24, 2003·The Journal of Biological Chemistry·Heather K LambAlastair R Hawkins
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
Feb 14, 2007·The Biochemical Journal·Nadine PollakMathias Ziegler
May 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Xiaofeng ZhengMing Luo
Feb 23, 2008·Science·P Rajesh KumarLeemor Joshua-Tor

❮ Previous
Next ❯

Citations

Jan 6, 2011·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Min-Kyu KimSa-Ouk Kang
Oct 12, 2010·PloS One·Carlos Guerrero-BosagnaMichael K Skinner
May 28, 2010·Protein Science : a Publication of the Protein Society·Xiao ZhaoAlastair R Hawkins
Jun 2, 2010·Molecular Cell·Krystle J McLaughlinClara L Kielkopf
Apr 4, 2021·Antioxidants·In-Gyun Lee, Bong-Jin Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.