Abstract
The purpose of this study was to assess the efficacy of diode laser combined with intradiscal vancomycin for iatrogenic discitis (ID) infected with Staphylococcus aureus. In vivo and in vitro studies have reported that diode laser has a potential bactericidal effect on S. aureus. The rabbit ID model was induced by injecting S. aureus into the intervertebral discs (IVDs). The animals were classified into the following groups: Group M, model; Group N, non-treatment; Group O, operation; Group V, vancomycin; Group L, laser; and Group C, laser with vancomycin. The rabbits were killed when paraplegia occurred and target IVD regions were removed for histopathological examination. In Group M, MRI findings revealed narrowing of the disc space, with changed T1 and T2 signals. In Group N, pathological examination showed a narrowed disc space, inflammatory changes in disc tissue, extensive erosion and hyperostosis of bony end plates, and an epidural abscess. Narrowed disc space and bone fusion were observed in Group O. In Group V, narrowed disc spaces, focal inflammatory changes of the disc tissue, and focal erosion and hyperostosis of bony end plates were seen. In Groups L and C, cavitation, inflammatory lesions, focal erosion, and hypero...Continue Reading
References
Oct 1, 1992·British Journal of Plastic Surgery·M F Stranc, F W Yang
Mar 1, 1990·The Journal of Bone and Joint Surgery. British Volume·O L OstiB Vernon-Roberts
Sep 1, 1989·Zeitschrift für Orthopädie und ihre Grenzgebiete·A Krödel, H Stürz
Apr 1, 1987·Spine·F J EismontR H Rothman
Dec 1, 1994·Spine·L H RileyF J Eismont
Oct 15, 1993·Spine·G J ScuderiF J Eismont
Feb 1, 1993·Acta Orthopaedica Scandinavica·M Rudert, B Tillmann
Jan 1, 1997·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·P EyselJ D Rompe
Jun 5, 2004·Hospital Medicine·Khai S Lam, John K Webb
Jul 11, 2006·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Rebecca WaltersRobert Moore
Feb 10, 2009·Applied and Environmental Microbiology·Michelle MacleanGerry Woolsey
Jul 28, 2010·Archives of Orthopaedic and Trauma Surgery·Fei WangJun Liu
Jan 11, 2011·Photomedicine and Laser Surgery·Nicole R S SantosAntonio L B Pinheiro
Jan 12, 2011·Photomedicine and Laser Surgery·Göksel Şimşek KayaHilal Balta
Feb 3, 2011·Lasers in Medical Science·Franziska BeerAndreas Moritz