Diode laser combined with intradiscal vancomycin for iatrogenic discitis: an experimental study in rabbits

Photomedicine and Laser Surgery
Tao WangWei-Guo Huang

Abstract

The purpose of this study was to assess the efficacy of diode laser combined with intradiscal vancomycin for iatrogenic discitis (ID) infected with Staphylococcus aureus. In vivo and in vitro studies have reported that diode laser has a potential bactericidal effect on S. aureus. The rabbit ID model was induced by injecting S. aureus into the intervertebral discs (IVDs). The animals were classified into the following groups: Group M, model; Group N, non-treatment; Group O, operation; Group V, vancomycin; Group L, laser; and Group C, laser with vancomycin. The rabbits were killed when paraplegia occurred and target IVD regions were removed for histopathological examination. In Group M, MRI findings revealed narrowing of the disc space, with changed T1 and T2 signals. In Group N, pathological examination showed a narrowed disc space, inflammatory changes in disc tissue, extensive erosion and hyperostosis of bony end plates, and an epidural abscess. Narrowed disc space and bone fusion were observed in Group O. In Group V, narrowed disc spaces, focal inflammatory changes of the disc tissue, and focal erosion and hyperostosis of bony end plates were seen. In Groups L and C, cavitation, inflammatory lesions, focal erosion, and hypero...Continue Reading

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Citations

Oct 4, 2012·Epilepsy & Behavior : E&B·W Curt LaFranceAndres M Kanner

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Methods Mentioned

BETA
biopsies
light microscopy

Software Mentioned

SPSS

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