Dioscin inhibits stem-cell-like properties and tumor growth of osteosarcoma through Akt/GSK3/β-catenin signaling pathway

Cell Death & Disease
Weihai LiuJun-qiang Yin

Abstract

Osteosarcoma is the most common primary bone tumor in children and adolescents. Many patients with osteosarcoma always develop drug resistance to current chemotherapy regimens, which induces a poor prognosis. And cancer stem cells (CSCs) have been reported to possess the properties to self-renew and maintain the phenotype of tumor, which may lead to clinical treatment failure. Thus, it is an urgent task to develop several potentially useful therapeutic agents, which could target CSCs in osteosarcoma. This study aims to clarify the in vitro and in vivo anti-osteosarcoma effects of dioscin, the primary component derived from Discorea nipponica Makino, and its molecular mechanism of action. In this study, all the ten human osteosarcoma cell lines were sensitive to dioscin treatment in a dose- and time-dependent manner. Dioscin inhibits proliferation and induces cell cycle arrest as well as apoptotic cell death in osteosarcoma cells. More importantly, oral administration of dioscin (60 mg/kg) showed significant therapeutic effect on osteosarcoma growth without obvious side effects in vivo. In addition, dioscin possesses the ability to suppress stem-cell-like phenotype of osteosarcoma cells. Mechanistically, dioscin inhibits osteosa...Continue Reading

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Citations

Jan 10, 2020·Chemical Communications : Chem Comm·Perrine RobinKogularamanan Suntharalingam
May 6, 2020·Cells·Przemysław DudaJames A McCubrey
May 18, 2020·Chembiochem : a European Journal of Chemical Biology·Arvin EskandariKogularamanan Suntharalingam
Apr 28, 2020·BMC Complementary Medicine and Therapies·Jinhong LengLing Zhang
Aug 4, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mei-Mei WuXiao-Jun Zhang
Jul 17, 2021·Chemistry : a European Journal·Zhiyin XiaoKogularamanan Suntharalingam
Dec 24, 2021·Cell Biology International·Weifei ZhangHui Zeng

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Methods Mentioned

BETA
PCR
flow cytometry
xenografts
xenograft

Software Mentioned

CellQuest
SPSS

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