Diosgenin as a Novel Alternative Therapy for Inhibition of Growth, Invasion, and Angiogenesis Abilities of Different Glioblastoma Cell Lines.

Neurochemical Research
Firas Khathayer, Swapan K Ray

Abstract

Fenugreek (Trigonella foenum-graecum) seeds and roots of wild yam (Dioscorea villosa) possess nutritional and medicinal properties and have been used for centuries in traditional medicine to treat different diseases and inflammatory responses. Diosgenin is a natural steroidal sapogenin extracted from fenugreek and wild yam and it is one of the major bioactive compounds used in the treatment of diabetes, hypercholesterolemia, and inflammation. Recent studies have shown a promising effect of diosgenin as an anti-tumor agent for inhibition of cell proliferation and induction of apoptosis in many cancers such as colon cancer, leukemia, breast cancer, and liver cancer. We examined the effects of different concentrations (5, 10, 15, 20, and 25 µM) of diosgenin on proliferation of rat C6 and human T98G glioblastoma cell lines. We noticed that diosgenin had a high inhibitory effect on the growth of both C6 and T98G cell lines. Diosgenin induced the differentiation of glioblastoma cells, as determined by the increase in the expression of the differentiation marker glial fibrillary acidic protein (GFAP); and decreased the dedifferentiation of the cells, as shown by the decrease in the abundance of the dedifferentiation marker proteins Id...Continue Reading

References

Nov 1, 1973·Journal of the National Cancer Institute·D J GiardW P Parks
Oct 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G KroemerB Mignotte
Feb 13, 1999·Nature Genetics·K J WuR Dalla-Favera
Sep 16, 2003·Angewandte Chemie·Lutz F TietzeSrivari Chandrasekhar
Mar 17, 2004·Cancer Treatment Reviews·Juan Angel Fresno VaraManuel González-Barón
Apr 10, 2004·Journal of Neuro-oncology·Rolf MentleinJanka Held-Feindt
Apr 16, 2005·Neuro-oncology·Balveen KaurErwin G Van Meir
Feb 6, 2007·Biochemical and Biophysical Research Communications·Magdalena DziembowskaBozena Kaminska
Jan 1, 2009·Nutrition and Cancer·Jayadev Raju, Rekha Mehta
Feb 7, 2009·Cancer Biology & Therapy·Shabana ShabbeerSaeed R Khan
Apr 23, 2009·International Journal of Cancer. Journal International Du Cancer·Sowmyalakshmi SrinivasanChendil Damodaran
Jun 27, 2009·Expert Opinion on Investigational Drugs·Cory AdamsonDarell D Bigner
Aug 24, 2010·Neurochemical Research·Hyo Sang JangJeffrey A Greenwood
Jun 22, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Dae Sung KimYeun Ja Mun
Jul 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Linlin LvJinyong Peng
Mar 25, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Zhongmei HeJiaming Sun
Apr 1, 2014·BMC Complementary and Alternative Medicine·Abdulaziz AlsemariAyodele Alaiya
Aug 9, 2015·Chinese Journal of Natural Medicines·Yan ChenBo-Yang Yu
Feb 20, 2016·Experimental and Therapeutic Medicine·Lei WangYinan Luo
Dec 23, 2016·Neuroscience Letters·Raffaela Silvestre IgnarroFabio Rogerio
Feb 1, 2018·EXCLI Journal·Jae Kwang Kim, Sang Un Park
Apr 5, 2018·Frontiers in Physiology·Elif Ozdemir-KaynakOzlem Yesil-Celiktas

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Methods Mentioned

BETA
Assay
Flow
flow cytometry
fluorescence imaging
protein assay
electrophoresis
X-Ray

Software Mentioned

GraphPad Prism
GraphPad
ImageJ

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