Diospyros kaki Extract Inhibits Alkali Burn-Induced Corneal Neovascularization

Journal of Medicinal Food
Sung Jae YangSang Hoon Jung

Abstract

The purpose of this study was to evaluate the effect of ethanol extract of Diospyros kaki (EEDK) leaves on corneal neovascularization (CoNV) in rats. One week after the alkali burns in the corneas, the CoNV area coverage in the CoNV-positive control group, 100 mg/kg EEDK group, and 200 mg/kg EEDK group was 43.3% ± 5.5%, 337.7% ± 2.5%, and 27.2% ± 4.3%, respectively. The areas of CoNV in the EEDK-treated groups were significantly different from those of the CoNV group. EEDK significantly attenuated the upregulation of vascular endothelial growth factor, fibroblast growth factor, interleukin-6, and matrix metalloproteinase-2 (MMP-2) protein levels. Orally administrated D. kaki inhibited CoNV development in rats.

References

Jul 1, 1997·Current Eye Research·C SotozonoS Kinoshita
Mar 23, 2001·Journal of Agricultural and Food Chemistry·S GorinsteinO Màrtín-Belloso
Aug 17, 2001·Current Opinion in Ophthalmology·J H ChangD T Azar
Apr 28, 2005·The American Journal of Pathology·Shizuya SaikaAnita B Roberts
Jul 28, 2005·Cytokine & Growth Factor Reviews·Robert M StrieterMichael P Keane
Jul 4, 2006·American Journal of Ophthalmology·Sophie J BakriRonald J Marler
Aug 12, 2009·Journal of Ethnopharmacology·Weijian BeiChuyuan Li
Dec 8, 2009·Bioscience, Biotechnology, and Biochemistry·Ryoichi IzuchiYumiko Inada
Oct 26, 2010·Medical Hypotheses·V Sánchez-HuertaJ Flores-Estrada
Aug 8, 2013·International Journal of Molecular Medicine·Hui-Hun KimSang-Hyun Kim

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Citations

Mar 5, 2016·Advances in Pharmacological Sciences·Fatemeh ForouzanfarHamid R Sadeghnia
Apr 20, 2019·Chemical Biology & Drug Design·Jiahao ZhangYan Zhang
May 30, 2019·Nutrients·María Fernanda Estrella-MendozaJavier Flores-Estrada
May 11, 2017·Chemical Biology & Drug Design·Xinyao LiuYan Zhang

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