Dioxin-Like TEQ of women from the Seveso, Italy area by ID-HRGC/HRMS and CALUX

Journal of Exposure Analysis and Environmental Epidemiology
Marcella WarnerPier Mario Gerthoux

Abstract

Polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) are widespread environmental contaminants that exist as complex mixtures and are frequently detected at part-per-trillion (ppt) levels in humans. Using isotope dilution high-resolution gas chromatography/ high-resolution mass spectrometry (HRGC/HRMS), we measure the PCDDs, PCDFs, and PCBs in serum of a population of 78 women residing in an area near Seveso, Italy where a TCDD explosion occurred in 1976 and where furniture is manufactured. The average total dioxin-like toxic equivalents (TEQ) of these women was 25.3 ppt, lipid-adjusted, comparable to other parts of Europe. TCDD levels, however, were higher among the few women who resided in the exposed area in 1976. We examined the possibility of using the CALUX (chemical-activated luciferase gene expression) bioassay to estimate total TEQ in a small volume of plasma from this population. A total of 32 archived plasma specimens were selected for CALUX bioassay, based on the distribution of Total TEQ by HRGC/HRMS. The CALUX bioassay was performed blind to HRGC/HRMS results with 2 ml plasma per replicate analysis. Of 32 samples, 10 were below detection limits in t...Continue Reading

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Citations

Oct 4, 2007·Journal of Exposure Science & Environmental Epidemiology·Kevin T ConnorJ Craig Rowlands
May 27, 2006·Environmental Health : a Global Access Science Source·Manhai LongEva C Bonefeld-Jorgensen
Oct 25, 2007·Environmental Health : a Global Access Science Source·Manhai LongEva C Bonefeld-Jorgensen
Nov 23, 2012·Environmental Health Perspectives·Marina VafeiadiManolis Kogevinas
Jul 9, 2005·Environmental Health Perspectives·Brenda EskenaziPaolo Mocarelli
Apr 14, 2007·Environmental Health Perspectives·Marcella WarnerPaolo Mocarelli
Oct 24, 2013·Journal of Exposure Science & Environmental Epidemiology·Marcella WarnerBrenda Eskenazi
Mar 1, 2012·Environment International·Dario ConsonniPier Alberto Bertazzi
Jun 25, 2009·Biochemical Pharmacology·Simon G HelyarJon G Mabley
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Dec 30, 2017·Environmental Research·Jennifer AmesBrenda Eskenazi

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