DIP1 plays an antiviral role against DCV infection in Drosophila melanogaster

Biochemical and Biophysical Research Communications
Qi ZhangQingfa Wu

Abstract

Disconnected Interacting Protein 1 (DIP1) is a dsRNA-binding protein that participates in a wide range of cellular processes. Whether DIP1 is involved in innate immunity remains unclear. Here, DIP1 was found to play an antiviral role in S2 cells. Its antiviral action is specific for DCV infection and not for DXV infection. dip1 mutant flies are hypersensitive to DCV infection. The increased mortality in dip1 mutant flies is associated with the accumulation of DCV positive-stranded RNAs in vivo. This study demonstrated that dip1 is a novel antiviral gene that restricts DCV replication in vitro and in vivo.

References

May 30, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laura R Saunders, Glen N Barber
Jul 3, 2004·Genes & Development·Katsutomo OkamuraMikiko C Siomi
May 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·Robert A ZambonLouisa P Wu
Mar 24, 2006·Nature Immunology·Delphine Galiana-ArnouxJean-Luc Imler
Apr 14, 2006·Cellular Microbiology·Robert A ZambonLouisa P Wu
Jan 5, 2007·Annual Review of Immunology·Bruno Lemaitre, Jules Hoffmann
Sep 26, 2007·Immunity·Andreas Pichlmair, Caetano Reis e Sousa
Oct 28, 2008·Nature Immunology·Safia DeddoucheJean-Luc Imler
Oct 16, 2009·PloS One·Alexandre CostaDavid Schneider
Jul 21, 2010·Biochemical and Biophysical Research Communications·Daniel J Catanese, Kathleen S Matthews
Aug 14, 2010·Nature Reviews. Immunology·Shou-Wei Ding
Jan 20, 2011·Nucleic Acids Research·Julia V Hartig, Klaus Förstemann
Sep 13, 2011·Nature Structural & Molecular Biology·Diane WuAndrew Z Fire
Oct 6, 2011·Biochemical and Biophysical Research Communications·Daniel J Catanese, Kathleen S Matthews
Feb 22, 2014·Current Opinion in Immunology·Christopher R MacKayEvelyn A Kurt-Jones

❮ Previous
Next ❯

Citations

Jul 1, 2016·Proceedings of the National Academy of Sciences of the United States of America·Marine PetitMaria-Carla Saleh
Jun 1, 2017·RNA·Liam KeeganMary O'Connell
Oct 4, 2017·Nature Communications·Jing Ting WongJun Wei Pek
Dec 29, 2020·Developmental and Comparative Immunology·Juliette Schneider, Jean-Luc Imler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.