Dipeptide Mimetic of the BDNF GSB-106 with Antidepressant-Like Activity Stimulates Synaptogenesis

Doklady. Biochemistry and Biophysics
T A GudashevaS B Seredenin

Abstract

Dipeptide mimetic of the brain-derived neurotrophic factor bis(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide (working name GSB-106), which reproduces the homodimeric structure of BDNF and the beta-turn of its fourth loop, activates TrkB, AKT, and ERK, exhibits neuroprotective and antidepressant activity, and is able to stimulate neurogenesis in the hippocamp of stressed mice. Using Western blot hybridization and synaptophysin (synaptogenesis marker), we showed the ability of chronically administered GSB-106 to stimulate synaptogenesis, increasing the synaptic density in the hippocamp by 50%. Under the same conditions, GSB-106 exhibited antidepressant activity (decreased (by 18%) immobility of animals in Porsolt test), which may be associated with the stimulation of neurogenesis and synaptogenesis in the hippocamp.

References

Feb 15, 1978·European Journal of Pharmacology·R D PorsoltM Jalfre
Oct 21, 2010·Doklady. Biochemistry and Biophysics·T A GudashevaS B Seredenin
Mar 13, 2012·Pharmacological Reviews·Anita E Autry, Lisa M Monteggia
Sep 25, 2012·Bioorganicheskaia khimiia·T A GudashevaS B Seredenin
Jul 19, 2016·Neurobiology of Disease·Eero Castrén, Masami Kojima
Oct 30, 2016·Neuroscience Letters·Min-Wang ZhangFang Han
Nov 16, 2016·Drug Design, Development and Therapy·Tatyana A GudashevaSergey B Seredenin
Nov 5, 2017·Doklady. Biochemistry and Biophysics·T A GudashevaS B Seredenin

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Citations

Apr 2, 2019·Current Pharmaceutical Design·Tatiana A GudashevaSergey B Seredenin
Jun 16, 2019·Doklady. Biochemistry and Biophysics·T A GudashevaS B Seredenin
May 27, 2021·CNS & Neurological Disorders Drug Targets·Tatiana A GudashevaSergey B Seredenin

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