Dipeptide Nanotubes Containing Unnatural Fluorine-Substituted β(2,3)-Diarylamino Acid and L-Alanine as Candidates for Biomedical Applications

Organic Letters
Andrea BonettiMaria Luisa Gelmi

Abstract

The synthesis and the structural characterization of dipeptides composed of unnatural fluorine-substituted β(2,3)-diarylamino acid and L-alanine are reported. Depending on the stereochemistry of the β amino acid, these dipeptides are able to self-assemble into proteolytic stable nanotubes. These architectures were able to enter the cell and locate in the cytoplasmic/perinuclear region and represent interesting candidates for biomedical applications.

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Citations

Jan 18, 2017·Journal of Peptide Science : an Official Publication of the European Peptide Society·Francesca SelminSara Pellegrino
Nov 6, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Silvia MarchesanKatie E Styan
Aug 3, 2017·Organic & Biomolecular Chemistry·Raffaella BucciSara Pellegrino

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