Dipeptidyl peptidase-4 inhibitor use and risk of diabetic retinopathy: A population-based study

Diabetes & Metabolism
N H KimS G Kim

Abstract

This study examined whether dipeptidyl peptidase (DPP)-4 inhibitor use is beneficial or harmful to diabetic retinopathy (DR) compared with other glucose-lowering agents in patients with type 2 diabetes (T2D). From a population-based cohort provided by the National Health Insurance Service in Korea, 67,743 adults with T2D were identified as having been treated with oral glucose-lowering agents between 2008 and 2013. Matching (1:1) was performed for two groups comparing ever-use (cases) and never-use (controls) of DPP-4 inhibitors (n=14,522 in each group). Cox regression analyses were used to assess risk of the following DR events: vitreous haemorrhage; vitrectomy or photocoagulation; intravitreal agent use; and blindness. During a median follow-up of 28.4 (14.0-45.2) months, there were 305 (in controls) and 342 (in cases) composite DR events. DPP-4 inhibitor ever-use was not associated with overall risk of composite DR events [adjusted hazard ratio (HR): 1.08, 95% CI: 0.93-1.26] compared with never-use, nor was the risk of each DR outcome increased with DPP-4 inhibitor therapy either. However, DPP-4 inhibitor administration for<12 months was associated with a greater risk of composite DR events (adjusted HR: 1.31, 95% CI: 1.09-1...Continue Reading

Citations

Apr 30, 2020·Ophthalmic Surgery, Lasers & Imaging Retina·Ehsan RahimyUNKNOWN VIVID and VISTA Study Investigators
Mar 7, 2021·Journal of Clinical Medicine·Wojciech MatuszewskiElżbieta Bandurska-Stankiewicz
Jul 3, 2021·Journal of Clinical Medicine·Eugene Yu-Chuan KangYih-Shiou Hwang

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