Dipeptidyl peptidase-4(DPP-4) inhibitors: promising new agents for autoimmune diabetes.

Clinical and Experimental Medicine
Xia WangZhiguang Zhou

Abstract

Dipeptidyl peptidase-4 (DPP-4) inhibitors constitute a novel class of anti-diabetic agents confirmed to improve glycemic control and preserve β-cell function in type 2 diabetes. Three major large-scale studies, EXAMINE, SAVOR-TIMI 53, and TECOS, have confirmed the cardiovascular safety profile of DPP-4 inhibitors. Based on these results, DPP-4 inhibitors have gained widespread use in type 2 diabetes treatment. It is currently unknown, however, whether DPP-4 inhibitors have similar therapeutic efficacy against autoimmune diabetes. Several in vitro and in vivo studies have addressed this issue, but the results remain controversial. In this review, we summarize experimental findings and preliminary clinical trial results, and identify potentially effective immune modulation targets of DPP-4 inhibitors for autoimmune diabetes.

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Citations

Feb 12, 2019·Diabetes/metabolism Research and Reviews·Silvina YohenaGustavo Frechtel
Jun 5, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Zhenbo ChenQinghe Yao
Sep 27, 2019·Therapeutic Advances in Chronic Disease·Shian-Ren LinChing-Feng Weng
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May 25, 2021·Experimental Dermatology·Lula María Nieto-BenitoRicardo Suárez-Fernández
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Jun 15, 2021·International Immunopharmacology·Shabnam RadbakhshAmirhossein Sahebkar
Aug 25, 2021·Bioorganic & Medicinal Chemistry·Shubham KumarAmit Mittal

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