Diphenhydramine overdose during pregnancy: lessons from the past

American Journal of Obstetrics and Gynecology
B C BrostR B Newman

Abstract

A primigravid woman was seen for the first time in a disoriented and combative state, with regular, painful uterine contractions. Evaluation revealed a negative illicit drug screen, no evidence of preeclampsia, and a nonfocal neurologic examination. Further workup revealed urinary diphenhydramine levels suggesting drug overdose. This case serves as a reminder of the oxytocin-like effects of diphenhydramine.

Citations

Aug 7, 2013·Dermatologic Therapy·Olubukola Babalola, Bruce E Strober
Feb 12, 2010·Allergy·M K ChurchUNKNOWN Global Allergy and Asthma European Network
May 14, 2016·Expert Review of Clinical Pharmacology·E RidoloG Senna
Jul 12, 2017·Obstetrics and Gynecology·Alice AbernathyRobert Egerman
Apr 5, 2002·The Journal of Perinatal & Neonatal Nursing·N A Gjere

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