PMID: 7009519Sep 1, 1980Paper

Diphenhydramine reduces endotoxin effects on lung vascular permeability in sheep

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
K L BrighamR E Bowers

Abstract

Because, in sheep, histamine-induced increased lung vascular permeability is prevented by diphenhydramine, we tested the effects of diphenhydramine on the sheep lung vascular response to endotoxin. We infused E. coli endotoxin (0.40-1.00 micrograms/kg) with and without diphenhydramine (3.0 mg/kg bolus + 1.5 mg . kg-1 . h-1) in the same unanesthetized sheep while measuring pulmonary arterial (Ppa) and left atrial (Pla) pressures, lung lymph flow (Qlym) and lymph (L) and plasma (P) protein concentrations. Endotoxin caused pulmonary hypertension soon after infusion (base-line Ppa = 22 +/- 3 (SE) cmH2O; after endotoxin Ppa = 40 +/- 2; P less than 0.05, n = 6) and after several hours an increase in permeability reflected in high flow of protein-rich lymph (base-line; Qlym = 7.5 +/- 1.4 (SE) ml/h, L/P protein concentration = 0.60 +/- 0.02: after endotoxin; Qlym = 21.4 +/- 3.1, P less than 0.05; L/P = 0.66 +/- 0.03, P less than 0.05). In the presence of diphenhydramine, endotoxin caused identical pressure changes but Qlym was lower during the period of increased permeability (16.7 +/- 3.0 (SE) ml/h, P less than 0.05 compared to endotoxin alone) and L/P protein concentration was similar (0.68 +/- 0.04, P = NS). We conclude that endogen...Continue Reading

Citations

Jan 1, 1983·Intensive Care Medicine·J H Newman
Feb 1, 1993·American Journal of Respiratory Cell and Molecular Biology·S K Leeper-WoodfordA A Fowler
Dec 1, 1994·The British Journal of Surgery·P D CareyH J Sugerman
Jan 1, 1982·Annals of the New York Academy of Sciences·A B MalikM V Tahamont
Apr 25, 2009·Acta Anaesthesiologica Scandinavica·E E AlyR Sanaka
Nov 9, 2016·Intensive Care Medicine Experimental·Mizuki HattoriYuichi Hattori
Aug 10, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Naoyuki MatsudaSatoshi Gando

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