Diphenylalanine self assembly: novel ion mobility methods showing the essential role of water

Analytical Chemistry
Thanh D Do, Michael T Bowers

Abstract

The mechanism and driving forces behind the formation of diphenylalanine (FF) nanotubes have attracted much attention in the past decades. The hollow structure of the nanotubes suggests a role for water during the self-assembly process. Here, we use novel ion-mobility mass spectrometry methods to probe the early oligomers formed by diphenylalanine peptides. Interestingly, water-bound oligomers are observed in nano-electrospray ionization (ESI) mass spectra in the absence of bulk solvent. In addition, ligated water clusters transit the ion mobility cell but (often) dissociate before detection. These water molecules are shown to be essential for the formation of diphenylalanine oligomers larger than the dimer. The ligated water molecules exist in the solvent free environment either as neutral water or as protonated water clusters, depending on the composition of solvent from which they are sprayed. Water adduction helps stabilize conformers that are otherwise energetically unstable ultimately leading to the assembly of FF nanotubes.

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Citations

Oct 21, 2015·The Journal of Physical Chemistry. B·Neil A EschmannSongi Han
Aug 6, 2015·Journal of the American Chemical Society·Thanh D DoMichael T Bowers
Aug 5, 2016·Chemical Society Reviews·Juan WangXuehai Yan
Nov 3, 2016·Physical Chemistry Chemical Physics : PCCP·Pavel ZelenovskiyAndrei Kholkin
Apr 27, 2018·Chemical Society Reviews·Danielle M Raymond, Bradley L Nilsson
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Jul 8, 2020·Chemical Society Reviews·Pu Chun KeRaffaele Mezzenga
May 26, 2017·Physical Chemistry Chemical Physics : PCCP·Chengqian YuanXuehai Yan
Apr 6, 2021·ACS Nano·Pavel Rehak, Petr Král
Apr 27, 2021·ACS Applied Materials & Interfaces·Jihyuk YangJi Tae Kim
Dec 10, 2016·The Journal of Physical Chemistry. B·Tarick J El-BabaDavid E Clemmer

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