Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an alpha-helix

Organic Letters
In Chul Kim, Andrew D Hamilton

Abstract

[structure: see text] The design of a nonpeptidic scaffold based on 4,7-diphenyl-1,6-disubstituted indanes mimicking i, i+3, i+4, and i+7 residues of an alpha-helix has been described, and its synthesis has been accomplished. This strategy makes general approaches possible to helix mimetic scaffolds that could be targeted to different proteins by changing the nature of the substituents.

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Citations

Dec 25, 2010·Journal of the American Chemical Society·Eunhwa KoKevin Burgess
Jan 28, 2011·Organic Letters·Eunhwa Ko, Kevin Burgess
Feb 1, 2007·Chemical Society Reviews·Jessica M DavisAndrew D Hamilton
May 8, 2010·Chemical Communications : Chem Comm·Jeffrey P PlanteAndrew J Wilson
Sep 26, 2015·Biology·Maryanna E Lanning, Steven Fletcher
May 20, 2014·Chembiochem : a European Journal of Chemical Biology·Xiangqian LiZhichao Zhang
Feb 21, 2013·Nature Chemistry·Valeria AzzaritoAndrew J Wilson
Sep 1, 2012·Chemistry : a European Journal·Marc J AdlerAndrew D Hamilton
May 10, 2007·Angewandte Chemie·Jorge Becerril, Andrew D Hamilton
Nov 1, 2007·Organic & Biomolecular Chemistry·James Garner, Margaret M Harding
Mar 6, 2009·Chembiochem : a European Journal of Chemical Biology·Johanna M RodriguezAndrew D Hamilton
May 8, 2010·Organic & Biomolecular Chemistry·Frederick CampbellAndrew J Wilson
Apr 20, 2007·Biopolymers·Ye CheGarland R Marshall
Apr 12, 2007·Biopolymers·Justin K Murray, Samuel H Gellman
Oct 15, 2013·Organic & Biomolecular Chemistry·Dongyue XinKevin Burgess
Apr 1, 2015·Chemical Science·Valeria AzzaritoAndrew J Wilson
Nov 22, 2008·Biochemical Society Transactions·Ishu Saraogi, Andrew D Hamilton
Apr 26, 2012·Organic & Biomolecular Chemistry·Sam Thompson, Andrew D Hamilton
Apr 13, 2011·Chemical Society Reviews·Eunhwa KoKevin Burgess
Jun 4, 2011·Journal of the American Chemical Society·Bishwajit PaulKent Kirshenbaum
Jul 12, 2011·The Journal of Organic Chemistry·Marc J Adler, Andrew D Hamilton
Jan 23, 2014·The Journal of Organic Chemistry·Lukas SpanierThomas Kurz

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