PMID: 16623542DOI: 10.1021/ol052956qApr 21, 2006Paper
Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an alpha-helix
Organic Letters
In Chul Kim, Andrew D Hamilton
Abstract
[structure: see text] The design of a nonpeptidic scaffold based on 4,7-diphenyl-1,6-disubstituted indanes mimicking i, i+3, i+4, and i+7 residues of an alpha-helix has been described, and its synthesis has been accomplished. This strategy makes general approaches possible to helix mimetic scaffolds that could be targeted to different proteins by changing the nature of the substituents.
References
Jan 1, 1996·Bioorganic & Medicinal Chemistry·D C HorwellH M Willems
Jun 1, 1996·Immunopharmacology·D HorwellG Ratcliffe
Apr 26, 2000·Chemistry & Biology·A G Cochran
Sep 1, 2000·Journal of Medicinal Chemistry·C García-EcheverríaP Furet
Feb 24, 2001·Protein Science : a Publication of the Protein Society·A M PetrosS W Fesik
Jul 18, 2001·Journal of the American Chemical Society·B P OrnerA D Hamilton
Dec 12, 2001·Current Opinion in Chemical Biology·A G Cochran
Oct 3, 2002·Journal of the American Chemical Society·Olaf KutzkiAndrew D Hamilton
Dec 20, 2002·Angewandte Chemie·Justin T ErnstAndrew D Hamilton
Dec 20, 2002·Angewandte Chemie·Brendan P OrnerAndrew D Hamilton
May 8, 2003·Journal of the American Chemical Society·Tami L RaguseSamuel H Gellman
Aug 5, 2004·Journal of the American Chemical Society·Joshua A KritzerAlanna Schepartz
May 17, 2002·Angewandte Chemie·Patrick Chene, Wolfgang Jahnke
❮ Previous
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Citations
Aug 21, 2013·Journal of Chemical Information and Modeling·Alexander MetzHolger Gohlke
Dec 25, 2010·Journal of the American Chemical Society·Eunhwa KoKevin Burgess
Jan 28, 2011·Organic Letters·Eunhwa Ko, Kevin Burgess
Feb 1, 2007·Chemical Society Reviews·Jessica M DavisAndrew D Hamilton
May 8, 2010·Chemical Communications : Chem Comm·Jeffrey P PlanteAndrew J Wilson
Sep 26, 2015·Biology·Maryanna E Lanning, Steven Fletcher
May 20, 2014·Chembiochem : a European Journal of Chemical Biology·Xiangqian LiZhichao Zhang
Feb 21, 2013·Nature Chemistry·Valeria AzzaritoAndrew J Wilson
Sep 1, 2012·Chemistry : a European Journal·Marc J AdlerAndrew D Hamilton
May 10, 2007·Angewandte Chemie·Jorge Becerril, Andrew D Hamilton
Nov 1, 2007·Organic & Biomolecular Chemistry·James Garner, Margaret M Harding
Mar 6, 2009·Chembiochem : a European Journal of Chemical Biology·Johanna M RodriguezAndrew D Hamilton
May 8, 2010·Organic & Biomolecular Chemistry·Frederick CampbellAndrew J Wilson
Apr 20, 2007·Biopolymers·Ye CheGarland R Marshall
Apr 12, 2007·Biopolymers·Justin K Murray, Samuel H Gellman
Jan 8, 2013·Chemistry : a European Journal·Martin PetersRolf Breinbauer
Oct 15, 2013·Organic & Biomolecular Chemistry·Dongyue XinKevin Burgess
Apr 1, 2015·Chemical Science·Valeria AzzaritoAndrew J Wilson
Nov 22, 2008·Biochemical Society Transactions·Ishu Saraogi, Andrew D Hamilton
Aug 10, 2011·Organic & Biomolecular Chemistry·Sachitanand M MaliHosahudya N Gopi
Apr 26, 2012·Organic & Biomolecular Chemistry·Sam Thompson, Andrew D Hamilton
Apr 13, 2011·Chemical Society Reviews·Eunhwa KoKevin Burgess
Jun 4, 2011·Journal of the American Chemical Society·Bishwajit PaulKent Kirshenbaum
Jan 25, 2014·Journal of Medicinal Chemistry·Ryan M BradyGuillaume Lessene
Jul 12, 2011·The Journal of Organic Chemistry·Marc J Adler, Andrew D Hamilton
Jan 23, 2014·The Journal of Organic Chemistry·Lukas SpanierThomas Kurz
Sep 11, 2013·Organic Letters·Devan NaduthambiNeal J Zondlo
Dec 25, 2009·Bioorganic & Medicinal Chemistry Letters·Radwan El-HaggarIkuo Fujii
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