Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands

Bioorganic & Medicinal Chemistry Letters
Masahiko KainumaYuichi Hashimoto

Abstract

Novel, potent farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor alpha (PPARalpha) agonists were obtained by using a diphenylmethane skeleton as a substitute for a steroid skeleton.

References

Apr 1, 1991·Cell Structure and Function·Y Hashimoto
May 21, 1999·Science·M MakishimaB Shan
Dec 1, 2001·Science·A ChawlaD J Mangelsdorf
May 23, 2002·Science·Makoto MakishimaDavid J Mangelsdorf
Oct 9, 2002·Mini Reviews in Medicinal Chemistry·Yuichi Hashimoto

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Citations

Jun 2, 2012·Future Medicinal Chemistry·Daniel MerkManfred Schubert-Zsilavecz
May 23, 2012·Molecular and Cellular Endocrinology·Tsutomu MatsubaraFrank J Gonzalez
Apr 13, 2017·Bioorganic & Medicinal Chemistry Letters·Takashi MisawaMasaaki Kurihara
May 19, 2009·Bioorganic & Medicinal Chemistry Letters·Shinnosuke HosodaYuichi Hashimoto
Dec 23, 2015·Organic & Biomolecular Chemistry·Kyle T HowardJohn D Chisholm
Apr 3, 2020·Chemical & Pharmaceutical Bulletin·Keisuke TsuchiyaTakashi Misawa
Nov 6, 2020·Chemical Communications : Chem Comm·Andrew R A SpencerIgor Larrosa
Oct 5, 2010·Bioorganic & Medicinal Chemistry Letters·Keisuke MaruyamaMinoru Ishikawa
Dec 9, 2014·Journal of the American Chemical Society·Zhaobin WangJianwei Sun
Aug 10, 2007·Bioorganic & Medicinal Chemistry Letters·Shinnosuke Hosoda, Yuichi Hashimoto
Mar 29, 2014·Journal of Medicinal Chemistry·Nathalie LagardeMatthieu Montes
Jun 9, 2009·Bioorganic & Medicinal Chemistry Letters·Shinnosuke HosodaYuichi Hashimoto

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