PMID: 9192297May 1, 1997Paper

Diphenylpiperazines enhance regeneration after facial nerve injury

Journal of Neurocytology
J X Tong, K M Rich

Abstract

Immature rat facial motoneurons are very sensitive to injury with nearly 80% dying during the first week after axotomy. This motoneuron death is apoptotic, similar to that induced in neurons after tropic factor withdrawal. The diphenylpiperazines, flunarizine and cinnarizine, protect dorsal root ganglion neurons from death after withdrawal of trophic support, i.e., nerve growth factor withdrawal, in vitro. Similarly, the monoamine oxidase inhibitor, deprenyl, promotes survival of facial motoneurons after axotomy. These pharmacological agents were assessed both alone and in combination for their ability to prevent death in non-nerve growth factor dependent CNS motoneurons after facial nerve axotomy in newborn rats. Long-term experiments were done with the diphenylpiperazines to evaluate potential enhancement of regeneration. Facial nerve transection resulted in 78% neuronal loss in the injured compared with the contralateral, uninjured nucleus. Systemic administration of diphenylpiperazines for 1 week after facial nerve transection doubled the number of surviving motoneurons from 23% to 47%. Similar results were obtained with deprenyl. Combinations of diphenylpiperazines and deprenyl provide a similar degree of neuronal protecti...Continue Reading

Citations

Oct 2, 2003·Clinical Neuropharmacology·Rahim Hobbenaghi, Taki Tiraihi
Jun 29, 2005·Journal of Psychopharmacology·Oscar P Dall'IgnaDiogo R Lara
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J ShiteC S Liang
Jun 7, 2019·Neural Regeneration Research·Ali Rashidiani-RashidabadiReza Mastery Farahni
Dec 18, 2007·Cellular and Molecular Neurobiology·Kapil SaxenaIshan Patro
May 22, 2008·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Sertac Yetiser, Erkan Kahraman
Jan 28, 2010·Pharmaceuticals·Thierry BordetRebecca M Pruss

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